39161-84-7 Usage
Description
4-Mercaptophenylacetic acid, also known as 4-MPA, is an organic compound with the chemical formula C8H8O2S. It is a white powder that serves as a synthetic intermediate and a redox buffer in various applications. Its unique structure, featuring a thiol group and a carboxylic acid, allows it to participate in various chemical reactions and processes.
Uses
Used in Pharmaceutical Industry:
4-Mercaptophenylacetic acid is used as a synthetic intermediate for the preparation of novel anti-inflammatory agents. Its unique chemical properties enable the development of new drugs with potential therapeutic benefits.
Used in Peptide Synthesis:
4-Mercaptophenylacetic acid is used as a synthetic intermediate in the preparation of small ubiquitin-like modifier peptides from bis(2-sulfanylethyl)amido peptide via sequential native chemical ligation. This application is crucial for the chemical synthesis of peptides, which have various biological functions and potential therapeutic applications.
Used in Chemical Ligation Process:
4-Mercaptophenylacetic acid is used in the on-resin preparation of peptide-α thiophenylesters, which are essential in a chemical ligation process. This process allows for the efficient synthesis of peptides and proteins with specific properties and functions.
Used in Protein Synthesis:
4-Mercaptophenylacetic acid is used in the one-pot deprotection of (acetamido-methyl)cysteine following native chemical ligation and/or desulfurization methods. This application aids in the preparation of peptides and proteins with specific properties, which can be challenging to synthesize using traditional methods.
Used in Redox Buffering:
4-Mercaptophenylacetic acid acts as a redox buffer that increases the folding rate of disulfide-containing proteins relative to traditional buffers such as glutathione and glutathione-disulfide. This application is particularly useful in the production of proteins with specific structural and functional properties.
Check Digit Verification of cas no
The CAS Registry Mumber 39161-84-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,1,6 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 39161-84:
(7*3)+(6*9)+(5*1)+(4*6)+(3*1)+(2*8)+(1*4)=127
127 % 10 = 7
So 39161-84-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H8O2S/c9-8(10)5-6-1-3-7(11)4-2-6/h1-4,11H,5H2,(H,9,10)
39161-84-7Relevant articles and documents
SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS
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Page/Page column 34; 35, (2016/12/07)
The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I), which are therapeutically useful as modulators of Retinoic acid receptor-related orphan receptors (RORs), more particularly as RORγ modulators. These co
FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS
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Page/Page column 33; 34, (2015/07/16)
The present invention provides fused thiophene and thiazole derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; in which R1, R2, R3, R4, R5, R6, R7, X1, X2, L, m, n and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in disease(s) or disorder(s) where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the fused thiophene and thiazole derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.
TRISUBSTITUTED HETEROCYCLIC DERIVATIVES AS ROR GAMMA MODULATORS
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Page/Page column 30; 31, (2014/09/03)
The present invention provides trisubstituted heterocyclic derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; (I) in which R1, R2, R3, Ra, X, L, m and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the trisubstituted heterocyclic derivatives of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor.
