39689-58-2

Basic information

• Product Name: 1H-Indole-6-aceticacid(9CI)
• Synonyms: 1H-Indole-6-aceticacid(9CI);1H-Indole-6-acetic acid;2-(1H-indol-6-yl)acetic acid;2-(1H-Indol-6-yl)
• CAS NO: 39689-58-2
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.19
• Product Categories: INDOLE
• Mol File: 39689-58-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 415.03 °C at 760 mmHg
• Flash Point: 204.803 °C
• Appearance: /
• Density: 1.354±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.43±0.30(Predicted)
• CAS DataBase Reference: 1H-Indole-6-aceticacid(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-6-aceticacid(9CI)(39689-58-2)
• EPA Substance Registry System: 1H-Indole-6-aceticacid(9CI)(39689-58-2)

Safety Data

• Hazardous Substances Data: 39689-58-2(Hazardous Substances Data)

Upstream product

• 50820-65-0 indole-6-carboxylic acid methyl ester 
• 127956-28-9 1-(tert-butoxycarbonyl)-1H-indole-6-carboxaldehyde 
• 39689-57-1 2-(1H-indol-6-yl)acetonitrile 
• 1196-70-9 indole-6-carboxaldehyde 

Downstream Products

• 876049-18-2 2-(1H-indol-6-yl)-N-prop-2-ynyl-acetamide 
• 119160-62-2 N-cyclopentylmethylindole-6-acetamide 
• 1146323-63-8 2-(1H-indol-6-yl)-N-{(1R)-1-[5-(2,2.2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide 
• 33140-85-1 methyl 2-(1H-indole-6-yl)acetate 

Relevant articles and documents

POLYHETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS

The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X-Y-Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Aliphatic carboxamides

This invention provides a series of novel heterocyclic aliphatic carboxamides of formula I in which the group >Z--Y--XC=CH--NN--CH=CC=N--NN--N=C and the other radicals have the meanings defined in the following specification. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.