39890-98-7

Basic information

• Product Name: 2,6-Dichloro-4-(trifluoromethyl)pyridine
• Synonyms: 2,6-DICHLORO-4-(TRIFLUOROMETHYL)PYRIDINE;4-TRIFLUOROMETHYL-2,6-DICHLOROPYRIDINE;4-TrifluoroMethyl-2,6-dichloroprydine;2,6-Dichloro-alpha,alpha,alpha-trifluoro-4-picoline
• CAS NO: 39890-98-7
• Molecular Formula: C₆H₂Cl₂F₃N
• Molecular Weight: 215.99
• EINECS: 201-525-2
• Product Categories: Pyridines;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building BlocksHeterocyclic Building Blocks;New Products for Chemical Synthesis;Aromatics;Heterocycles;Intermediates;Fluorine series
• Mol File: 39890-98-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 85°C 40mm
• Flash Point: 70-75°C/25mm
• Appearance: /
• Density: 1.505 g/mL at 25 °C
• Vapor Pressure: 0.594mmHg at 25°C
• Refractive Index: n20/D 1.473
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -4.51±0.10(Predicted)
• CAS DataBase Reference: 2,6-Dichloro-4-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-4-(trifluoromethyl)pyridine(39890-98-7)
• EPA Substance Registry System: 2,6-Dichloro-4-(trifluoromethyl)pyridine(39890-98-7)

Safety Data

• Hazard Codes: T,F,Xi
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45
• RIDADR: UN2810
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 39890-98-7(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

2,6-Dichloro-4-(trifluoromethyl)pyridine is a tri-substituted pyridine used in the preparation of pharmaceuticals agents with antitumor activities.

InChI:InChI=1/C6H4FNO/c7-6-1-5(4-9)2-8-3-6/h1-4H

Upstream product

• 339539-97-8 4-trifluoromethyl-3H-pyridine-2,6-dione 
• 356518-29-1 4-trifluoromethyl-2,6-piperidinedione 
• 36610-32-9 4-hydroxy-4-trifluoromethyl-1,6-heptadiene 
• 36610-31-8 3-hydroxy-3-trifluoromethyl-1,5-pentanedicarboxylic acid 
• 339539-96-7 3-hydroxy-3-trifluoromethyl-1,5-pentanedialdehyde 
• 4162-55-4 3-(trifluoromethyl)pentanedioic acid 
• 4759-65-3 3-(trifluoromethyl)glutaric anhydride 

Downstream Products

• 326894-74-0 2-iodo-4-(trifluoromethyl)pyridine 
• 100366-76-5 2,6-diiodo-4-(trifluoromethyl)pyridine 
• 503437-19-2 2,6-dichloro-4-trifluoromethylnicotinic acid 
• 387880-99-1 (2,3,4-trimethoxy-6-methylphenyl)(2,6-dichloro-4-trifluoromethyl-pyridin-3-yl)methanol 
• 1000152-84-0 2,6-dibromo-4-(trifluoromethyl)pyridine 
• 34486-23-2 6-chloro-4-(trifluoromethyl)pyridin-2-amine 
• 1163142-47-9 6-chloro-N,N-diethyl-4-(trifluoromethyl)pyridin-2-amine 
• 130171-52-7 4-(trifluoromethyl)pyridine-2,6-diamine 
• 1201675-03-7 4-(6-chloro-4-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester 
• 1263374-80-6 6-chloro-N-(3-fluorobenzyl)-4-(trifluoromethyl)pyridin-2-amine 
• 1160994-99-9 2-chloro-6-methoxy-4-(trifluoromethyl)pyridine 
• 1332875-23-6 6-chloro-N-(4-methoxybenzyl)-4-(trifluoromethyl)pyridin-2-amine 
• 1332875-22-5 2-(3-tert-butyl-isoxazol-5-yl)-7-trifluoromethyl-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine 
• 1332875-24-7 (4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine 

Relevant articles and documents

SUBSTITUTED AZOLE DIONE COMPOUNDS WITH ANTIVIRAL ACTIVITY

Provided herein are methods of using substituted azole dione compounds for treatment of viral infections.

Convenient approaches to 4-trifluoromethylpyridine

A number of approaches to the synthesis of 2-chloro-and 2,6-dichloro-4-trifluoromethylpyridine are described. The first method for 2-chloro-and 2,6-dichloro-4-trifluoromethylpyridine is based on commercially available ethyl trifluoroacetate. An alternative access to 2,6-dichloro-4-trifluoromethyl pyridine uses trifluoroacetaldehyde as starting material. 2-Chloro-4-trifluoromethylpyridine is prepared from ethyl(trifluoroacetylvinyl)ether in two steps.

Synthesis of novel analogues of marine indole alkaloids: Mono(indolyl)-4-trifluoromethylpyridines and bis(indolyl)-4-trifluoromethylpyridines as potential anticancer agents

Mono(indolyl)-4-trifluoromethylpyridines and bis(indolyl)-4-trifluoromethylpyridines were synthesized using Suzuki cross-coupling reaction between 2-chloro-4-trifluoromethylpyridine 9, 2,6-dichloro-4-trifluoromethylpyridine 6 or 2,6-dichloro-3-cyano-4-tri