503437-19-2Relevant articles and documents
Preparation method and application of N-cyanomethyl bis(trifluoromethyl) nicotinamide
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Paragraph 0021; 0022; 0027, (2017/11/04)
The invention discloses a preparation method of N-cyanomethyl bis(trifluoromethyl) nicotinamide. The preparation method is implemented according to the following steps of: by adopting 2, 6-dichloro-3-cyano-4-tirfluoromethyl pyridine as a material, carrying out nitrile-group hydrolysis, hydrogenolysis and amidation reaction, and finally preparing the N-cyanomethyl bis(trifluoromethyl) nicotinamide, wherein the filtrate generated in the amidation reaction can be used as a reaction solvent for amidation reaction again after heating filtration and cooling filtration to prepare the N-cyanomethyl bis(trifluoromethyl) nicotinamide. The N-cyanomethyl bis(trifluoromethyl) nicotinamide prepared by adopting the preparation method is 71.1-85.7% in yield and 99.1-99.9%, and can be applied as a standard product for detecting the content of flonicamid and calibrating the content of impurities in the preparation process. The preparation method is applicable to preparing the N-cyanomethyl bis(trifluoromethyl) nicotinamide and monitoring flonicamid.
1,6-naphthyridine derivatives and their use to treat diabetes and related disorders
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Page/Page column 48, (2010/02/05)
The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,6-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.