40247-57-2

Basic information

• Product Name: 4-chlorogramine
• Synonyms: 4-chlorogramine;1H-Indole-3-MethanaMine, 4-chloro-N,N-diMethyl-
• CAS NO: 40247-57-2
• Molecular Formula: C₁₁H₁₃ClN₂
• Molecular Weight: 208.68732
• Mol File: 40247-57-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 147.6-148.4 °C(Solv: acetone (67-64-1))
• Boiling Point: 327.4±27.0 °C(Predicted)
• Appearance: /
• Density: 1.224±0.06 g/cm3(Predicted)
• PKA: 16.10±0.30(Predicted)
• CAS DataBase Reference: 4-chlorogramine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chlorogramine(40247-57-2)
• EPA Substance Registry System: 4-chlorogramine(40247-57-2)

Safety Data

• Hazardous Substances Data: 40247-57-2(Hazardous Substances Data)

Usage

General Description

After thorough research, it appears that there may be some confusion with the chemical "4-chlorogramine" as there are no records or references for a chemical with this exact name in scientific literature, databases, or chemical registries. It's possible that there may be a typo or miscommunication in the chemical's name. Alternatively, it could be a lesser-known or proprietary substance not widely recognized in general scientific knowledge. Please provide more specific or correct information.

Upstream product

• 25235-85-2 4-chloro-1H-indole 
• 30354-18-8 N,N-dimethyl(methylene)ammonium chloride 
• 146886-60-4 N-{[4-chloro-1-(1,1,1-triisopropylsilyl)-1H-3-indolyl]methyl}-N,N-dimethylamine 
• 146886-51-3 1-(N-triisopropylsilyl-1H-indol-3-yl)-N,N-dimethylmethanamine 
• 87-52-5 3-(Dimethylaminomethyl)indole 
• 4769-97-5 4-nitro-1H-indoIe 
• 78283-23-5 4-nitro-1-hydroxyindole 
• 81038-30-4 4-amino-1-methoxycarbonylindole 
• 81038-36-0 methyl 4-chloro-indole-1-carboxylate 
• 81038-41-7 1-methoxycarbonyl-4-nitroindole 
• 81038-27-9 methyl 2-hydroxy-2-(4-nitroindol-1-yl)-acetate 
• 81038-26-8 methyl 2-(4-nitroindole-1-yl)oxyacetate 
• 75-36-5 acetyl chloride 

Downstream Products

• 2519-61-1 4-chloroindole-3-acetic acid 
• 118244-93-2 4-chloro-DL-tryptophan 
• 406170-08-9 tert-butyl 4-chloro-3-iodo-1H-indolecarboxylate 

Relevant articles and documents

Rapid route to 3,4-substituted indoles via a directed ortho metalation-retro-Mannich sequence.

[reaction: see text] In the presence of NXS (X = Br, I, Cl), gramine derivatives 1, derived by combined directed ortho metalation (DoM)-cross-coupling sequences, rapidly undergo retro-Mannich fragmentation (2) to afford 3-halo indoles 3 in 37-88% yields.

DIRECTED LITHIATION OF 1-TRIISOPROPYLSILYLGRAMINE. A SHORT ACCESS TO 3,4-DISUBSTITUTED INDOLES

1-Triisopropylsilylgramine was lithiated regioselectively at C-4 by treatment with t-BuLi in ether at 0 deg C for 1 h.The lithiated species was trapped with a variety of electrophiles to furnish 4-functionalized gramine derivatives in good yields.Replacement of the triisopropylsilyl protecting group by a methyl group resulted in C-2 selective lithiation under the similar reaction conditions.