406-10-0 Usage
Description
Ethyl 4,4,4-trifluorobut-2-enoate, also known as ethyl 4,4,4-trifluorocrotonate, is an organic compound that features a trifluoromethyl group and a double bond in its structure. It is a key intermediate in the synthesis of various chemical compounds and has been utilized in the preparation of specific pyroglutamic acids.
Uses
Used in Pharmaceutical Synthesis:
Ethyl 4,4,4-trifluorobut-2-enoate is used as a key intermediate in the synthesis of (2S,3S)-3-methyland (2S,3S)-3-trifluoromethylpyroglutamic acid. Its application is due to its ability to undergo diastereoselective Michael addition reactions with ethyl crotonate, which is crucial for the development of these pharmaceutical compounds.
Used in Chemical Research:
In the field of chemical research, ethyl 4,4,4-trifluorobut-2-enoate is used as a reactant in the study of the Michael reaction between itself and a Ni(II) complex of the Schiff base of glycine with (S)-o-[N-(N-benzylprolyl)amino]benzophenone. This application is significant for understanding the reaction mechanisms and potential applications in the synthesis of complex organic molecules.
Overall, ethyl 4,4,4-trifluorobut-2-enoate plays a vital role in both pharmaceutical synthesis and chemical research, showcasing its versatility and importance in the development of new compounds and understanding reaction mechanisms.
Check Digit Verification of cas no
The CAS Registry Mumber 406-10-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,0 and 6 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 406-10:
(5*4)+(4*0)+(3*6)+(2*1)+(1*0)=40
40 % 10 = 0
So 406-10-0 is a valid CAS Registry Number.
406-10-0Relevant articles and documents
Synthesis method for 4,4,4-trifluoro-crotonates
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Paragraph 0037; 0040; 0041; 0042; 0044; 0049; 0054; 0060, (2019/01/16)
The invention relates to a synthesis method for 4,4,4-trifluoro-crotonates. The problems that in the prior art, the conversion rate of 3,3,3-trifluoro-allylene is low, and the selectivity of 4,4,4-trifluoro-crotonates is low are mainly solved. The preparing method for the 4,4,4-trifluoro-crotonates includes the step that the 3,3,3-trifluoro-allylene, materials of carbon monoxide and alcohol and acatalyst composition are subjected to a contact reaction to obtain the 4,4,4-trifluoro-crotonates, wherein the catalyst composition comprises a rhodium complex and a high-valence-metal-cation-ocene diphosphonic compound in the technical scheme; the technical problems are well solved, and the synthesis method can be used for industrial production of the 4,4,4-trifluoro-crotonates.
METHOD FOR PREPARATION OF FLUORO, CHLORO AND FLUOROCHLORO ALKYLATED COMPOUNDS BY HOMOGENEOUS CATALYSIS
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Page/Page column 21; 22, (2016/06/01)
The invention discloses a method for preparation of fluoro, chloro and fluorochloro alkylated compounds by homogeneous Pd catalyzed fluoro, chloro and fluorochloro alkylation with fluoro, chloro and fluorochloroalkyl halides in the presence of di(1-adamantyl)-n-butylphosphine and in the presence of 2,2,6,6-tetramethylpiperidine 1-oxyl.
METABOTROPIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF
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Page/Page column 90, (2013/02/27)
Compounds that modulate GluR5 activity and methods of using the same are disclosed.
