40899-93-2

Basic information

• Product Name: 1-(PHENYLSULFONYL)-1H-INDOLE-2-CARBOXYLIC ACID
• Synonyms: RARECHEM AL BE 1292;1-(PHENYLSULFONYL)-1H-INDOLE-2-CARBOXYLIC ACID;1-PHENYLSULPHONYLINDOLE-2-CARBOXYLIC ACID;BUTTPARK 98\04-09;1-(Phenylsulphonyl)-1H-indole-2-carboxylic acid
• CAS NO: 40899-93-2
• Molecular Formula: C₁₅H₁₁NO₄S
• Molecular Weight: 301.32
• Mol File: 40899-93-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 170 °C
• Boiling Point: 570.7°C at 760 mmHg
• Flash Point: 299°C
• Appearance: /
• Density: 1.4g/cm³
• Vapor Pressure: 7.27E-14mmHg at 25°C
• Refractive Index: 1.663
• PKA: 3.67±0.30(Predicted)
• CAS DataBase Reference: 1-(PHENYLSULFONYL)-1H-INDOLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(PHENYLSULFONYL)-1H-INDOLE-2-CARBOXYLIC ACID(40899-93-2)
• EPA Substance Registry System: 1-(PHENYLSULFONYL)-1H-INDOLE-2-CARBOXYLIC ACID(40899-93-2)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 40899-93-2(Hazardous Substances Data)

Usage

General Description

1-(Phenylsulfonyl)-1H-indole-2-carboxylic acid is a chemical compound with potential pharmaceutical applications. It belongs to the class of indole derivatives and has a structure consisting of an indole ring attached to a carboxylic acid group and a phenylsulfonyl substituent. 1-(PHENYLSULFONYL)-1H-INDOLE-2-CARBOXYLIC ACID may have the potential to exhibit biological activity due to its structural features and is a subject of research for its potential use in drug development. Its properties and potential applications make it an interesting compound for further study and investigation.

InChI:InChI=1/C15H11NO4S/c17-15(18)14-10-11-6-4-5-9-13(11)16(14)21(19,20)12-7-2-1-3-8-12/h1-10H,(H,17,18)

Upstream product

• 124-38-9 carbon dioxide 
• 99275-44-2 2-iodo-1-(phenylsulfonyl)-1H-indole 
• 40899-71-6 1-benzenesulfonylindole 
• 40899-92-1 ethyl 1-(phenylsulfonyl)-1H-indole-2-carboxylate 
• 120-72-9 indole 
• 98-09-9 benzenesulfonyl chloride 
• 3770-50-1 2-carbethoxyindole 
• 1477-50-5 Indole-2-carboxylic acid 
• 1202-04-6 indole-2-carboxylic acid methyl ester 

Downstream Products

• 106154-53-4 1-Benzenesulfonyl-1H-indole-2-carboxylic acid diethylamide 
• 60376-48-9 methyl 1-(phenylsulfonyl)-1H-indole-2-carboxylate 
• 342405-28-1 1-phenylsulfonyl-1H-2-indolecarboxylic acid chloride 
• 540740-51-0 1-benzenesulfonyl-1H-indole-2-carboxylic acid hydrazide 
• 896137-83-0 (5-fluoro-1-phenylsulfonyl-1H-indol-2-yl)-(1-phenylsulfonyl-1H-indol-2-yl)methanone 
• 1477-50-5 Indole-2-carboxylic acid 
• 145662-43-7 2,3-Dibromo-1-(phenylsulfonyl)indole 
• 1239864-83-5 1-methyl-4-(phenyl-sulfonyl)-1H-furo[3,4-b]indol-3(4H)-one 
• 1352536-81-2 C₁₉H₂₁N₃O₄S 
• 1352536-84-5 C₂₂H₂₇N₃O₄S 
• 1352536-86-7 C₂₀H₁₉NO₄S 
• 1352536-91-4 C₂₁H₂₁NO₃S 
• 1239864-88-0 N-benzenesulfonyl-2-(N',N'-dimethylhydrazinecarbonyl)indole 
• 89241-38-3 1,3-dimethyl-4-(phenylsulfonyl)-4H-furo[3,4-b]indole 

Relevant articles and documents

N-(piperidin-4-yl)-1H-indole-2-carboxamide derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating Urotensin-Ⅱ receptor activity related diseases containing the same as an active ingredient

The present invention relates to N-(piperidin-4-yl)-1H-indole-2-carboxamide derivatives, a preparation method thereof, and a pharmaceutical composition for preventing or treating urotensin-II receptor activity-related diseases comprising the same as activ

BINHIBITORS OF HEPATITIS B VIRUS CONVALENTLY CLOSED CIRCULAR DNA FORMATION AND THEIR METHOD OF USE

Pharmaceutical compositions of the invention comprise covalently closed circular DNA formation inhibitors having a disease-modifying action in the treatment of diseases associated with the formation of covalently closed circular DNA that include hepatitis B infection, and any disease involving formation of covalently closed circular DNA.

Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase

FLT3 receptor tyrosine kinase is aberrantly active in many cases of acute myeloid leukemia (AML). Recently, bis(1H-indol-2-yl)methanones were found to inhibit FLT3 and PDGFR kinases. To optimize FLT3 activity and selectivity, 35 novel derivatives were synthesized and tested for inhibition of FLT3 and PDGFR autophosphorylation. The most potent FLT3 inhibitors 98 and 102 show IC 50 values of 0.06 and 0.04 μM, respectively, and 1 order of magnitude lower PDGFR inhibiting activity. The derivatives 76 and 82 are 20- to 40-fold PDGFR selective. Docking at the recent FLT3 structure suggests a bidentate binding mode with the backbone of Cys-694. Activity and selectivity can be related to interactions of one indole moiety with a Hydrophobic pocket including Phe-691, the only different binding site residue (PDGFR Thr-681). Compound 102 inhibited the proliferation of 32D cells expressing wildtype FLT3 or FLT3-ITD similarly as FLT3 autophosphorylation, and induced apoptosis in primary AML patient blasts.