41645-07-2

Basic information

• Product Name: Acetamide, N-[2-[1-(phenylmethyl)-1H-indol-3-yl]ethyl]-
• CAS NO: 41645-07-2
• Molecular Formula: C19H20N2O
• Molecular Weight: 292.381
• Mol File: 41645-07-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[2-[1-(phenylmethyl)-1H-indol-3-yl]ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[2-[1-(phenylmethyl)-1H-indol-3-yl]ethyl]-(41645-07-2)
• EPA Substance Registry System: Acetamide, N-[2-[1-(phenylmethyl)-1H-indol-3-yl]ethyl]-(41645-07-2)

Safety Data

• Hazardous Substances Data: 41645-07-2(Hazardous Substances Data)

Upstream product

• 1016-47-3 N-Acetyltryptamine 
• 100-39-0 benzyl bromide 
• 3377-71-7 N-benzylindole 
• 62005-48-5 N-acetylaminoacetaldehyde dimethyl acetal 
• 61-54-1 tryptamine 
• 4307-98-6 N-benzyltryptamine 
• 108-24-7 acetic anhydride 

Downstream Products

• 181363-99-5 N¹⁰-acetyl-N¹⁰-[5,6-dicarbomethoxy-3-(1,2,4-triazinyl)]-N¹-benzyltryptamine 
• 181364-00-1 N¹⁰-acetyl-N¹⁰-[6-methylthio-3-(1,2,4,5-tetrazinyl)]-N¹-benzyltryptamine 
• 1446147-06-3 C₂₀H₁₉F₃N₂O₂S 
• 1391153-78-8 C₂₁H₂₂N₂O₃ 

Relevant articles and documents

Synthesis of tryptamine derivatives via a direct, one-pot reductive alkylation of indoles

An efficient, one-pot reductive alkylation of indoles with N-protected aminoethyl acetals in the presence of TES/TFA is reported. It represents the first general method for the direct synthesis of tryptamine derivatives from indoles and nitrogen-functionalized acetals. This convergent and versatile approach employs safe and inexpensive reagents, proceeds under mild conditions, and tolerates several functional groups. The new procedure was efficiently applied to a gram-scale synthesis of both luzindole, a reference MT2-selective melatonin receptor antagonist, and melatonin.

Intramolecular inverse electron demand Diels-Alder reactions of tryptamine with tethered heteroaromatic azadienes

1,2,4,5-Tetrazines and 1,2,4-triazines tethered to tryptamine via the ethylamine side chain undergo intramolecular inverse electron demand cycloadditions to produce adducts with the [ABazaCE]-ring skeleton of the Aspidosperma alkaloids. (C) 2000 Elsevier Science Ltd.