4307-98-6

Basic information

• Product Name: 2-(1-BENZYL-1H-INDOL-3-YL)-ETHYLAMINE
• Synonyms: RARECHEM AN KA 0328;2-(1-BENZYL-1H-INDOL-3-YL)-ETHYLAMINE;2-(1-BENZYL-INDOL-3-YL)-ETHYLAMINE
• CAS NO: 4307-98-6
• Molecular Formula: C₁₇H₁₈N₂
• Molecular Weight: 250.34
• Mol File: 4307-98-6.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 448.9°C at 760 mmHg
• Flash Point: 225.3°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 3E-08mmHg at 25°C
• Refractive Index: 1.609
• CAS DataBase Reference: 2-(1-BENZYL-1H-INDOL-3-YL)-ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-BENZYL-1H-INDOL-3-YL)-ETHYLAMINE(4307-98-6)
• EPA Substance Registry System: 2-(1-BENZYL-1H-INDOL-3-YL)-ETHYLAMINE(4307-98-6)

Safety Data

• Hazardous Substances Data: 4307-98-6(Hazardous Substances Data)

Usage

General Description

2-(1-benzyl-1H-indol-3-yl)-ethylamine is a chemical compound with a molecular formula C20H22N2 and a molecular weight of 290.4 g/mol. It is also known as N-(1-benzyl-1H-indol-3-yl)ethylamine and is classified as an organic amine. 2-(1-BENZYL-1H-INDOL-3-YL)-ETHYLAMINE is a derivative of the indole system, which is a heterocyclic aromatic organic compound. It is used in chemical research and may have potential applications in the fields of medicinal chemistry and drug development due to its unique structure and potential biological activities. Additionally, it may be used in the synthesis of various pharmaceuticals and other biologically active compounds.

InChI:InChI=1/C17H18N2/c18-11-10-15-13-19(12-14-6-2-1-3-7-14)17-9-5-4-8-16(15)17/h1-9,13H,10-12,18H2

Upstream product

• 6346-09-4 4-aminobutyrylaldehyde diethylacetal 
• 614-31-3 N-benzyl-N-phenylhydrazine 
• 59414-85-6 2-(1-benzyl-1H-indol-3-yl)acetonitrile 
• 176242-83-4 (E)-1-benzyl-3-(2-nitrovinyl)-1H-indole 
• 61-54-1 tryptamine 
• 100-39-0 benzyl bromide 
• 264619-79-6 N¹-benzyl-N¹⁰-BOC-tryptamine 
• 100-44-7 benzyl chloride 
• 874916-37-7 2-(2-(1-benzyl-1H-indol-3-yl)ethyl)isoindoline-1,3-dione 
• 15741-71-6 N-phthalimidotryptamine 
• 103549-24-2 tert-butyl [2-(1H-indol-3-yl)ethyl]carbamate 
• 487-89-8 Indole-3-carboxaldehyde 
• 10511-51-0 1-Benzylindole-3-carboxaldehyde 
• 771-51-7 indole-3-acetonitrile 

Downstream Products

• 41645-07-2 N¹-benzyl-N^ω-acetyltryptamine 
• 142605-13-8 9-benzyl-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole 
• 82605-23-0 2-Methyl-5-oxo-hexanoic acid [2-(1-benzyl-1H-indol-3-yl)-ethyl]-amide 
• 116246-38-9 1-benzyl-N-formyltryptamine 
• 1053700-69-8 (3aS,4S,6R,6aR)-6-{6-[2-(1-Benzyl-1H-indol-3-yl)-ethylamino]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide 
• 181363-96-2 N¹⁰-[3-(1,2,4,5-tetrazinyl)]-N¹-benzyltryptamine 
• 184001-61-4 hex-5-enoic acid [2-(1-benzyl-1H-indol-3-yl)ethyl]amide 
• 264619-96-7 N¹-benzyl-N¹⁰-(pent-4-ynoyl)tryptamine 
• 264619-81-0 N¹⁰-[5,6-dicarbomethoxy-3-(1,2,4-triazinyl)]-N¹-benzyltryptamine 
• 264619-80-9 N¹⁰-[6-methylthio-3-(1,2,4,5-tetrazinyl)]-N¹-benzyltryptamine 
• 264619-99-0 N¹⁰-[6-chloro-3-(1,2,4,5-tetrazinyl)]-N¹-benzyltryptamine 
• 264619-94-5 N¹⁰-[6-methyl-3-(1,2,4,5-tetrazinyl)]-N¹-benzyltryptamine 
• 328058-70-4 N-[2-(1-benzyl-1H-indol-3-yl)ethyl]-4-(phenylsulfanyl)butyramide 
• 328058-71-5 N-[2-(1-benzyl-1H-indol-3-yl)ethyl]-5-(phenylsulfanyl)pentanamide 

Relevant articles and documents

Diels-Alder Cycloaddition of Azepino[4,5-b]indoles Towards Hydrocarbazole Derivatives and Related Heterocycles

An approach to hydrocarbazoles bearing an all-carbon quaternary center at C4a position was developed via a Br?nsted acid-initiated Diels-Alder cycloaddition/retro-aza-Michael addition cascade process from azepino[4,5-b]indoles and commercially available d

Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria

The last three decades have seen a dwindling number of novel antibiotic classes approved for clinical use and a concurrent increase in levels of antibiotic resistance, necessitating alternative methods to combat the rise of multi-drug resistant bacteria. A promising strategy employs antibiotic adjuvants, non-toxic molecules that disarm antibiotic resistance. When co-dosed with antibiotics, these compounds restore antibiotic efficacy in drug-resistant strains. Herein we identify derivatives of tryptamine, a ubiquitous biochemical scaffold containing an indole ring system, capable of disarming colistin resistance in the Gram-negative bacterial pathogens Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli while having no inherent bacterial toxicity. Resistance was overcome in strains carrying endogenous chromosomally-encoded colistin resistance machinery, as well as resistance conferred by the mobile colistin resistance-1 (mcr-1) plasmid-borne gene. These compounds restore a colistin minimum inhibitory concentration (MIC) below the Clinical & Laboratory Sciences Institute (CLSI) breakpoint in all resistant strains.

Ynesulfonamide-Based Silica Gel and Alumina-Mediated Diastereoselective Cascade Cyclizations to Spiro[indoline-3,3′-pyrrolidin]-2-ones under Neat Conditions

The spiro[indoline-3,3′-pyrrolidin]-2-ones were synthesized via a silica gel and alumina-mediated sequential transformation based on tryptamine-derived ynesulfonamide substrates under neat conditions. The inherent tendency of C?C bond migration through Wagner-Meerwein rearrangement in the synthesis of spirooxindole was prevented by water trapping to the spiroindoleninium intermediate. The functional group tolerances of the methodology were investigated using a variety of substrates. The detailed mechanism of the sequential transformation was probed by the isotope-labeled experiments. This strategy was further applied in the formal syntheses of indole alkaloids coerulescine and horsfiline. (Figure presented.).