41806-40-0Relevant articles and documents
Efficient synthesis of trisimidazole and glutaric acid bearing porphyrins: Ligands for active-site models of bacterial nitric oxide reductase
Collman, James P.,Yan, Yi-Long,Lei, Jianping,Dinolfo, Peter H.
, p. 923 - 926 (2007/10/03)
Ligands (1) for active-site models of bacterial nitric oxide reductase (NOR) have been efficiently synthesized. These compounds (1) feature three imidazolyl moieties and one carboxylic acid residue at the FeB site, which represent the closest available synthetic model ligands of NOR active center. The stereo conformations of these ligands are established on the basis of steric effects and 1H NMR chemical shifts under the ring current effect of the porphyrin.
Synthesis of xestomanzamines a and b
Burm, Brigitte E.A.,Blokker, Peter,Jongmans, Edwin,Van Kampen, Erwin,Wanner, Martin J.,Koomen, Gerrit-Jan
, p. 495 - 503 (2007/10/03)
Synthetic pathways are described for the synthesis of two naturally occurring β-carbolines, xestomanzamine A and B. The synthesis of aromatic xestomanzamine A was most conveniently achieved by way of a Grignard reaction in dichloromethane. This route is suitable for the synthesis of analogues with modifications in the imidazole ring of xestomanzamine A. Xestomanzamine B, an oxidation-sensitive dihydro-β-carboline, was prepared by Pictet-Spengler condensation of tryptamine with a vicinal tricarbonyl substituted imidazole.
Preparation of 1-alkylimidazoles
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, (2008/06/13)
Process for the preparation of 1-alkylimidazoles of the general formula (I) STR1 where R1 is alkyl, R2 and R3 are hydrogen, alkyl, aryl, arylalkyl, or alkylaryl, R4 is carboxy, alkoxycarbonyl R5 OCC--, carbamoyl, or cyano, and R5 is an alkyl of from 1 to 8 carbon atoms--by the reaction of imidazoles of the general formula (II) STR2 with dialkyl sulfates of the general formula (III) at elevated temperatures in the presence of a carboxylic acid or anhydride or of both acid and anhydride.
