42580-43-8

Basic information

• Product Name: 2-Bromo-4-aminomethylaniline
• Synonyms: 2-Bromo-4-aminomethylaniline
• CAS NO: 42580-43-8
• Molecular Weight: 201.066
• Mol File: 42580-43-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Bromo-4-aminomethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-aminomethylaniline(42580-43-8)
• EPA Substance Registry System: 2-Bromo-4-aminomethylaniline(42580-43-8)

Safety Data

• Hazardous Substances Data: 42580-43-8(Hazardous Substances Data)

Upstream product

• 873-74-5 4-Aminobenzonitrile 
• 50397-74-5 2-bromo-4-cyanoaniline 

Downstream Products

• 882677-98-7 tert-butyl N-3-bromo-4-[(methylsulfonyl)amino]benzylcarbamate 
• 882671-52-5 tert-butyl N-(4-amino-3-bromobenzyl)carbamate 

Relevant articles and documents

Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: Structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents

Recently, 1,3-diarylalkyl thioureas have merged as one of the promising nonvanilloid TRPV1 antagonists possessing excellent therapeutic potential in pain regulation. In this paper, the full structure-activity relationship for TRPV1 antagonism of a novel series of 1,3-diarylalky thioureas is reported. Exploration of the structure-activity relationship, by systemically modulating three essential pharmacophoric regions, led to six examples of 1,3-dibenzyl thioureas, which exhibit Ca2+ uptake inhibition in rat DRG neuron with IC50 between 10 and 100 nM.

Monoazo and diazo colorants from aminoalkylanilines and bis(aminoalkyl)anilines

Water-insoluble azo dyestuffs of the formula STR1 AND WATER-SOLUBLE ACID ADDITION SALTS THEREOF USEFUL FOR COLORING NATURAL FIBERS, SYNTHETIC FIBER-FORMING MATERIAL AND CELLULOSIC MATERIALS AS WELL AS IN THE MANUFACTURE OF PAPER, VARNISHES, INKS, COATINGS AND PLASTICS IN WHICH A represents an azoic coupling radical derived from a coupling component selected from the group consisting of arylides of hydroxysubstituted carbocyclic aromatic carboxylic acids, 1-aryl-5-hydroxypyrazoles, 6-amino-1-naphthol-3-sulfonic acid, and compounds having an enolizable ketomethylene group of the formula STR2 R is hydrogen, lower-alkyl, lower-alkoxy or halogen; R2 is hydrogen, lower-alkyl, lower-alkoxy, halogen, aminomethyl or 2-aminoethyl with the proviso that A is other than β-naphthol when R2 is aminomethyl or 2-aminoethyl; R1 and R3 are the same or different and are each hydrogen, lower-alkyl, lower-alkoxy, halogen or aminomethyl with the proviso that at least one of R1 and R3 is aminomethyl when R2 is other than aminomethyl or 2-aminoethyl; and n represents an integer whose value is 1 or 2 and corresponds to the number of azo linkages, which dyestuffs are obtained by coupling a diazotized amine of the formula STR3 in which R, R1, R2 and R3 are as defined above with said coupling component.