882671-52-5

Basic information

• Product Name: tert-butyl N-(4-amino-3-bromobenzyl)carbamate
• Synonyms: tert-butyl N-(4-amino-3-bromobenzyl)carbamate
• CAS NO: 882671-52-5
• Molecular Weight: 301.183
• Mol File: 882671-52-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl N-(4-amino-3-bromobenzyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N-(4-amino-3-bromobenzyl)carbamate(882671-52-5)
• EPA Substance Registry System: tert-butyl N-(4-amino-3-bromobenzyl)carbamate(882671-52-5)

Safety Data

• Hazardous Substances Data: 882671-52-5(Hazardous Substances Data)

Upstream product

• 873-74-5 4-Aminobenzonitrile 
• 50397-74-5 2-bromo-4-cyanoaniline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 42580-43-8 2-Bromo-4-aminomethylaniline 

Downstream Products

• 882677-98-7 tert-butyl N-3-bromo-4-[(methylsulfonyl)amino]benzylcarbamate 

Relevant articles and documents

Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: Structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents

Recently, 1,3-diarylalkyl thioureas have merged as one of the promising nonvanilloid TRPV1 antagonists possessing excellent therapeutic potential in pain regulation. In this paper, the full structure-activity relationship for TRPV1 antagonism of a novel series of 1,3-diarylalky thioureas is reported. Exploration of the structure-activity relationship, by systemically modulating three essential pharmacophoric regions, led to six examples of 1,3-dibenzyl thioureas, which exhibit Ca2+ uptake inhibition in rat DRG neuron with IC50 between 10 and 100 nM.