427878-02-2

Basic information

• Product Name: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxaMide, N-ethyl-4-[[5-[(MethoxyaMino)carbonyl]-2-Methylphenyl]aMino]-5-Methyl-
• Synonyms: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxaMide, N-ethyl-4-[[5-[(MethoxyaMino)carbonyl]-2-Methylphenyl]aMino]-5-Methyl-;N-Ethyl 4-((5-(MethoxycarbaMoyl)-2-Methylphenyl)-aMino)-5-Methylpyrrolo[2,1-f ][1,2,4]triazine-6-carboxaMide;N-ethyl-4-[5-(methoxycarbamoyl)-2-methylanilino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
• CAS NO: 427878-02-2
• Molecular Formula: C₁₉H₂₂N₆O₃
• Molecular Weight: 382.41638
• Mol File: 427878-02-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.34±0.1 g/cm3(Predicted)
• PKA: 12.17±0.46(Predicted)
• CAS DataBase Reference: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxaMide, N-ethyl-4-[[5-[(MethoxyaMino)carbonyl]-2-Methylphenyl]aMino]-5-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxaMide, N-ethyl-4-[[5-[(MethoxyaMino)carbonyl]-2-Methylphenyl]aMino]-5-Methyl-(427878-02-2)
• EPA Substance Registry System: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxaMide, N-ethyl-4-[[5-[(MethoxyaMino)carbonyl]-2-Methylphenyl]aMino]-5-Methyl-(427878-02-2)

Safety Data

• Hazardous Substances Data: 427878-02-2(Hazardous Substances Data)

Upstream product

• 1005196-62-2 4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid 
• 557-66-4 ethanamine hydrochloride 
• 134653-70-6 ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate 
• 5448-16-8 3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 427878-69-1 1-amino-3-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 427878-70-4 ethyl 4-hydroxy-5-methylpyrrolo[2,1-f ][1,2,4]-triazine-6-carboxylate 

Downstream Products

• 623153-08-2 C₂₈H₃₁N₇O₃ 

Relevant articles and documents

Development of a practical synthesis of a p38 kinase inhibitor via a safe and robust amination

The development of a practical synthesis for a p38 kinase inhibitor is described. The key advances include an improved route to the key intermediate, a substituted pyrrole, and a subsequent animation utilizing O-(4-nitrobenzoyl)- hydroxylamine, which provides a safe, scalable, and robust amination method. The new protocol was successfully demonstrated to generate 1.6 kg of API in seven steps and 26% overall yield.