4295-04-9

Basic information

• Product Name: 4-CHLORO-6-METHOXYQUINOLINE
• Synonyms: 4-CHLORO-6-METHOXYQUINOLINE;6-Methoxy-4-chloro quinoline
• CAS NO: 4295-04-9
• Molecular Formula: C₁₀H₈ClNO
• Molecular Weight: 193.63
• EINECS: -0
• Mol File: 4295-04-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 79-79.5 °C
• Boiling Point: 299.9 °C at 760 mmHg
• Flash Point: 135.2 °C
• Appearance: /
• Density: 1.268 g/cm³
• Vapor Pressure: 0.00207mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.61±0.16(Predicted)
• CAS DataBase Reference: 4-CHLORO-6-METHOXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-6-METHOXYQUINOLINE(4295-04-9)
• EPA Substance Registry System: 4-CHLORO-6-METHOXYQUINOLINE(4295-04-9)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 4295-04-9(Hazardous Substances Data)

Usage

Chemical Properties

yellow powder

InChI:InChI=1/C10H8ClNO/c1-13-7-2-3-10-8(6-7)9(11)4-5-12-10/h2-6H,1H3

Upstream product

• 124-41-4 sodium methylate 
• 703-61-7 2,4-dichloroquinoline 
• 6563-13-9 6-methoxyquinoline N-oxide 

Downstream Products

• 858278-69-0 4-chloro-2-(4-chloro-phenyl)-6-methoxy-quinoline 
• 5450-23-7 (6-methoxy-[4]quinolylmercapto)-acetic acid 
• 50593-72-1 4-chloro-6-methoxy-2-phenylquinoline 
• 109448-40-0 6-methoxy-4-p-tolylmercapto-quinoline 
• 857439-28-2 N-(6-methoxy-[4]quinolyl)-o-phenylenediamine 
• 3517-61-1 4,6-dihydroxyquinoline 
• 148018-29-5 4-chloro-quinolin-6-ol 
• 23432-39-5 4-hydroxy-6-methoxyquinoline 
• 6279-51-2 6-methoxy-4-aminoquinoline 
• 180990-48-1 6-Methoxy-4-phenylsulfanyl-quinoline 
• 858278-70-3 4-chloro-2-(3-chloro-phenyl)-6-methoxy-quinoline 
• 180990-49-2 2-Ethynyl-6-methoxy-4-phenylsulfanyl-2H-quinoline-1-carboxylic acid phenyl ester 
• 180990-50-5 4-Benzenesulfinyl-2-ethynyl-6-methoxy-2H-quinoline-1-carboxylic acid phenyl ester 
• 180990-51-6 4-Benzenesulfonyl-2-ethynyl-6-methoxy-2H-quinoline-1-carboxylic acid phenyl ester 

Relevant articles and documents

A practical and mild chlorination of fused heterocyclic N-oxides

Fused azine N-oxides were selectively chlorinated at C2 in moderate to excellent yields, employing Vilsmeier reagent as both the activating agent and the nucleophilic chloride source. Remarkable features of the method include simple operation, mild reaction conditions, a wide substrate scope, and the use of only stoichiometric amount of POCl3. The potential extension of this method to a one-pot oxidation/chlorination sequence that obviates the need for isolation of the N-oxide intermediates is also validated.

N-HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT FOR THE TREATMENT OF PARASITIC DISEASES

This invention relates to certain N-heteroaryl compounds that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of the N-heteroaryl compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.