4330-99-8 Usage
Description
Trimeprazine tartrate, also known as (±)10-[3-(dimethylamino)-2-methylpropyl] phenothiazine tartrate (Temaril), is a white to off-white crystalline powder that is freely soluble in water and soluble in alcohol. It is a potent antihistamine with antihistaminic action reported to be 1.5 to 5 times that of promethazine. Trimeprazine tartrate exhibits a pronounced antipruritic action, which may be unrelated to its histamine-antagonizing properties.
Uses
Used in Pharmaceutical Industry:
Trimeprazine tartrate is used as an antipruritic agent for its pronounced antipruritic action, which may be unrelated to its histamine-antagonizing properties. It is particularly effective in treating itching and allergic reactions.
Used in Antimicrobial Applications:
Trimeprazine tartrate is used as an antibacterial and antimicrobial agent due to its ability to inhibit the growth of certain bacteria and microorganisms, making it useful in various medical and healthcare settings.
Used in Veterinary Medicine:
In the veterinary industry, Trimeprazine tartrate is used as an antihistamine and antipruritic agent for the treatment of itching and allergic reactions in animals, similar to its use in human medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 4330-99-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,3 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 4330-99:
(6*4)+(5*3)+(4*3)+(3*0)+(2*9)+(1*9)=78
78 % 10 = 8
So 4330-99-8 is a valid CAS Registry Number.
InChI:InChI=1/2C18H22N2S.C4H6O6/c2*1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20;5-1(3(7)8)2(6)4(9)10/h2*4-11,14H,12-13H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..0/s1
4330-99-8Relevant articles and documents
Reactions of thiyl radicals with phenothiazines and other antioxidants in aqueous solutions. A pulse radiolysis study.
Lal, Manohar,Mahal, H. S.
, p. 1376 - 1382 (2007/10/02)
Reaction rate constants of thiyl radicals with phenothiazines, promethazine (PMZ), chlorpromazine (CPZ), prochlorperazine (PPZ), trimeperazine tarterate (TPZ), and other antioxidants, e. g., ascorbic acid and 2,2-azinobis(3-ethyl benzthiazoline-6 sulphonate) (ABTS) have been estimated using pulse radiolysis technique.In general they are quite high (108-109 M-1 s-1).The k value of cysteine, cysteamine, mercaptoethanol, and mercaptopropionic acid with similar structures and molecular weights are more or less similar for PMZ, CPZ, and PPZ.Rate constants are lower in value for PenS., DT.T, DT.E and GuS. radicals of phenothiazines showing that they are dependent upon the structure and the molecular weight of the compound. Rate constants are the same whether the thiyl radicals are generated from thiols or their corresponding disulphides.The k values for chlorine-containing phenothiazines, chlorpromazine, and prochlorperazine are higher than those of promothazine.