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4385-04-0

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4385-04-0 Usage

Description

N,N-Dimethylhexylamine, a colorless liquid, is an organic compound with the chemical formula C8H19N. It is known for its various applications in different industries, particularly in pharmaceutical and analytical chemistry.

Uses

1. Analytical Chemistry:
N,N-Dimethylhexylamine is used as an ion-pairing agent for studying the poor retention of uridine diphosphate-linked intermediates on reverse phase media. This application aids in improving the analysis and understanding of these intermediates, which are crucial in various biochemical processes.
2. Food Industry:
In the food industry, specifically for baby foods, N,N-Dimethylhexylamine is utilized in determining the presence and concentration of five monophosphate nucleotides (cytidine 5′-monophosphate, uridine 5′-monophosphate, adenosine 5′-monophosphate, inosine 5′-monophosphate, and guanosine 5′-monophosphate). These nucleotides are essential for the proper development and functioning of the immune system in infants.
3. Pharmaceutical Industry:
Used in Cancer Treatment:
N,N-Dimethylhexylamine acts as an additive and is encapsulated into nanoparticles along with salinomycin (Sali), a compound with selective toxicity to cancer stem cells (CSCs). This combination enhances the delivery and effectiveness of salinomycin, targeting and eliminating CSCs, which are responsible for tumor recurrence and resistance to conventional cancer treatments.

Synthesis Reference(s)

Synthesis, p. 996, 1981 DOI: 10.1055/s-1981-29677

Check Digit Verification of cas no

The CAS Registry Mumber 4385-04-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,8 and 5 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 4385-04:
(6*4)+(5*3)+(4*8)+(3*5)+(2*0)+(1*4)=90
90 % 10 = 0
So 4385-04-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H19N/c1-4-5-6-7-8-9(2)3/h4-8H2,1-3H3/p+1

4385-04-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
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  • Alfa Aesar

  • (A17364)  N,N-Dimethylhexylamine, 99%   

  • 4385-04-0

  • 5g

  • 501.0CNY

  • Detail
  • Alfa Aesar

  • (A17364)  N,N-Dimethylhexylamine, 99%   

  • 4385-04-0

  • 25g

  • 1516.0CNY

  • Detail
  • Alfa Aesar

  • (A17364)  N,N-Dimethylhexylamine, 99%   

  • 4385-04-0

  • 100g

  • 5329.0CNY

  • Detail

4385-04-0Relevant articles and documents

Green and chemo selective amine methylation using methanol by an organometallic ruthenium complex

Abbasi, Alireza,Dindar, Sara,Nemati Kharat, Ali

, (2021/11/16)

Herein a green and convenient catalytic N-methylation of aniline and n-hexylamine using methanol as a dual methylation agent and solvent has been investigated. A new ruthenium carbonyl complex was synthesized and applied as a homogeneous catalyst in methylation reaction. The solid-state structure of the complex was determined by X-ray crystallographic analysis which indicate xantphos ligand bonded to ruthenium (II) as a tridentate pincer ligand by two P donor and one O atom. The catalytic system showed excellent conversion and selectivity toward N-methylaniline, and N,N-hexyldimethylamine at 140°C.

Deoxygenative hydroboration of primary, secondary, and tertiary amides: Catalyst-free synthesis of various substituted amines

An, Duk Keun,Jaladi, Ashok Kumar,Kim, Hyun Tae,Yi, Jaeeun

, (2021/11/17)

Transformation of relatively less reactive functional groups under catalyst-free conditions is an interesting aspect and requires a typical protocol. Herein, we report the synthesis of various primary, secondary, and tertiary amines through hydroboration of amides using pinacolborane under catalyst-free and solvent-free conditions. The deoxygenative hydroboration of primary and secondary amides proceeded with excellent conversions. The comparatively less reactive tertiary amides were also converted to the corresponding N,N-diamines in moderate yields under catalyst-free conditions, although alcohols were obtained as a minor product.

Reaction of Diisobutylaluminum Borohydride, a Binary Hydride, with Selected Organic Compounds Containing Representative Functional Groups

Amberchan, Gabriella,Snelling, Rachel A.,Moya, Enrique,Landi, Madison,Lutz, Kyle,Gatihi, Roxanne,Singaram, Bakthan

supporting information, p. 6207 - 6227 (2021/05/06)

The binary hydride, diisobutylaluminum borohydride [(iBu)2AlBH4], synthesized from diisobutylaluminum hydride (DIBAL) and borane dimethyl sulfide (BMS) has shown great potential in reducing a variety of organic functional groups. This unique binary hydride, (iBu)2AlBH4, is readily synthesized, versatile, and simple to use. Aldehydes, ketones, esters, and epoxides are reduced very fast to the corresponding alcohols in essentially quantitative yields. This binary hydride can reduce tertiary amides rapidly to the corresponding amines at 25 °C in an efficient manner. Furthermore, nitriles are converted into the corresponding amines in essentially quantitative yields. These reactions occur under ambient conditions and are completed in an hour or less. The reduction products are isolated through a simple acid-base extraction and without the use of column chromatography. Further investigation showed that (iBu)2AlBH4 has the potential to be a selective hydride donor as shown through a series of competitive reactions. Similarities and differences between (iBu)2AlBH4, DIBAL, and BMS are discussed.

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