(S)-1-phenyl-ethylamine
glyoxal trimer dihydrate
N,N'-bis<(S)-1-phenylethyl>ethanediimine
Conditions | Yield |
---|---|
With magnesium sulfate In dichloromethane for 5h; | 100% |
glyoxal trimer dihydrate
1,4,7,10-tetraazacyclododecan
cyclen-glyoxal
Conditions | Yield |
---|---|
In methanol at 0℃; for 3h; | 99% |
In methanol at 0 - 20℃; for 2.5h; | 94% |
In methanol; water at 20℃; for 3h; | 82% |
(S)-1-(4-methoxyphenyl)ethylamine
glyoxal trimer dihydrate
Conditions | Yield |
---|---|
In ethanol for 0.333333h; Reflux; | 96% |
Conditions | Yield |
---|---|
In isopropyl alcohol for 1h; Reflux; | 96% |
Conditions | Yield |
---|---|
In isopropyl alcohol for 1h; Reflux; | 95% |
Conditions | Yield |
---|---|
Stage #1: glyoxal trimer dihydrate With ammonium acetate; ammonia In tetrahydrofuran at -78℃; for 0.833333h; Inert atmosphere; Stage #2: cyclohexanone In tetrahydrofuran at -78 - 23℃; for 8h; Inert atmosphere; | 90% |
Conditions | Yield |
---|---|
With isopropyl alcohol at 50 - 55℃; for 1h; | 90% |
1,4,8,11-Tetraazacyclotetradecane
glyoxal trimer dihydrate
decahydro-1H,6H-3a,5a,8a,10a-tetraazapyrene
Conditions | Yield |
---|---|
In methanol; water at 20℃; for 2h; | 87% |
N,N'-dimethylsulfamide
glyoxal trimer dihydrate
Conditions | Yield |
---|---|
With hydrogenchloride at 35 - 40℃; for 1.5h; | 85% |
(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-8-oxooctanoate
glyoxal trimer dihydrate
(5)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(1H-imidazol-2-yl)heptanoate
Conditions | Yield |
---|---|
With ammonia In methanol at 20℃; for 72h; Sealed tube; | 85% |
With ammonia In methanol at 20℃; for 72h; Sealed tube; |
glyoxal trimer dihydrate
phenylhydrazine
glyoxal bis(phenylhydrazone)
Conditions | Yield |
---|---|
In methanol; water at 20℃; for 13h; | 83% |
glyoxal trimer dihydrate
(S)-4-Benzyl-2-oxazolidinone
Conditions | Yield |
---|---|
With sulfuric acid In chloroform at 20℃; for 12h; Pictet-Spengler Synthesis; diastereoselective reaction; | 82% |
With sulfuric acid In chloroform for 6h; Reflux; | 68.9% |
glyoxal trimer dihydrate
ethylenediamine
trans-1,4,6,9-tetraazabicyclo[4.4.0]decane
Conditions | Yield |
---|---|
With acetic acid In ethanol Condensation; | 80% |
glyoxal trimer dihydrate
ethylenediamine
decahydropyrazino[2,3-b]pyrazine
Conditions | Yield |
---|---|
With acetic acid In ethanol at 0 - 80℃; for 0.666667h; | 80% |
glyoxal trimer dihydrate
bis[1-methyl-1-mesitylcyclobutane-3-yl]-3-(1-oxyethyl)sulfide
Conditions | Yield |
---|---|
Stage #1: glyoxal trimer dihydrate In methanol for 1h; Heating; Stage #2: bis[1-methyl-1-mesitylcyclobutane-3-yl]-3-(1-oxyethyl)sulfide With sodium methylate In 1,4-dioxane; methanol for 0.5h; | 78% |
glyoxal trimer dihydrate
Conditions | Yield |
---|---|
Stage #1: glyoxal trimer dihydrate In methanol for 1h; Heating; Stage #2: bis[1-methyl-1-(2-tetralino)cyclobutane-3-yl]-3-(1-oxyethyl)sulfide With sodium methylate In 1,4-dioxane; methanol for 0.5h; | 75% |
formaldehyd
3β-amino-17-(1H-benzimidazole-1-yl)androsta-5,16-diene
glyoxal trimer dihydrate
Conditions | Yield |
---|---|
With ammonium hydroxide In methanol; water at 70℃; for 5h; Inert atmosphere; | 75% |
With ammonium hydroxide In methanol; water at 70℃; for 5h; | 74.8% |
N,N'-dipropylsulfamide
glyoxal trimer dihydrate
Conditions | Yield |
---|---|
With hydrogenchloride at 35 - 40℃; for 1.5h; | 74% |
Conditions | Yield |
---|---|
With hydrogenchloride at 35 - 40℃; for 1.5h; | 72% |
glyoxal trimer dihydrate
Conditions | Yield |
---|---|
With 4A molecular sives In tetrahydrofuran Heating; | 72% |
N,N'-Di-sek.-butyl-schwefelsaeurediamid
glyoxal trimer dihydrate
Conditions | Yield |
---|---|
With hydrogenchloride at 35 - 40℃; for 1.5h; | 71% |
Conditions | Yield |
---|---|
With ammonium hydroxide In methanol; water at 70℃; for 5h; Inert atmosphere; | 71% |
With ammonium hydroxide In methanol; water at 70℃; for 5h; | 70.7% |
glyoxal trimer dihydrate
(S)-N-tert-butoxycarbonylvalinal
(S)-tert-butyl (1-(1H-imidazol-2-yl)-2-methylpropyl)carbamate
Conditions | Yield |
---|---|
With ammonia In methanol at 20℃; | 70.1% |
glyoxal trimer dihydrate
Boc-L-phenylalaninal
(S)-tert-butyl (1-(1H-imidazol-2-yl)-2-phenylethyl)carbamate
Conditions | Yield |
---|---|
With ammonia In methanol at 0 - 20℃; for 48h; Inert atmosphere; | 70% |
With ammonia In methanol at 20℃; for 48h; | 47% |
glyoxal trimer dihydrate
N,N-diphenylthiourea
B
4,5-dihydroxy-1,3-diphenylimidazolidine-2-thione
Conditions | Yield |
---|---|
With potassium carbonate In water; isopropyl alcohol for 1h; pH=7.5; Reflux; diastereoselective reaction; | A 70% B n/a |
glyoxal trimer dihydrate
bis[1-methyl-1-phenylcyclobutane-3-yl]-3-(1-oxyethyl)sulfide
Conditions | Yield |
---|---|
Stage #1: glyoxal trimer dihydrate In methanol for 1h; Heating; Stage #2: bis[1-methyl-1-phenylcyclobutane-3-yl]-3-(1-oxyethyl)sulfide With sodium methylate In 1,4-dioxane; methanol for 0.5h; | 68% |
N-ethyl-N'-methyl-sulfamide
glyoxal trimer dihydrate
Conditions | Yield |
---|---|
With hydrogenchloride at 35 - 40℃; for 1.5h; | 67% |