442853-29-4Relevant articles and documents
Caged compounds with a steroid skeleton: Synthesis, liposome-formation and photolysis
Watanabe, Soichiro,Hiratsuka, Remi,Kasai, Yosuke,Munakata, Kazunori,Takahashi, Yasuhiro,Iwamura, Michiko
, p. 1685 - 1691 (2007/10/03)
The synthesis of two key precursors for caging bioactive compounds, an o-nitrobenzyl p-nitrophenyl carbonate and an o-nitrobenzyl diazo compound with a steroid skeleton, is reported. The former is a suitable caging group for an amino group, while the latter is appropriate for a carboxylic acid. The resulting caged compounds were irradiated at 350nm to afford the corresponding amine and carboxylic acid. A caged compound released bioactive compounds more efficiently when embedded in liposome than when in methanol.