446-29-7Relevant articles and documents
Simple and environment-friendly chemical synthesis method of 4-fluoro-2-methyl benzoic acid
-
Paragraph 0003, (2020/04/02)
The invention relates to a simple and environment-friendly chemical synthesis method of 4-fluoro-2-methyl benzoic acid. According to the synthesis method, m-fluorotoluene and acetyl chloride are takenas starting raw materials, and are subjected to a Friedel-Crafts acylation reaction under the catalytic action of anhydrous aluminum trichloride, a haloform reaction is carried out with sodium hypochlorite, two isomers of 4-fluoro-2-methyl benzoic acid and 2-fluoro-4-methyl benzoic acid are simultaneously obtained after hydrolysis, and the isomers are separated through re-crystallizing so as to obtain the target product 4-fluoro-2-methylbenzoic acid. The route is mild in reaction condition, low in cost, environment-friendly and suitable for industrial production.
Novel 5-HT2A receptor ligands
-
Page/Page column 9, (2010/02/11)
Compounds of formula I: are antagonists of the human 5-HT2A receptor, and hence useful in treatment or prevention of a variety of neurological conditions.