454451-67-3

Basic information

• Product Name: (3S)-(8S)-(8aR)-methyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-8-carboxylic acid methyl ester
• Synonyms: (3S)-(8S)-(8aR)-methyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-8-carboxylic acid methyl ester
• CAS NO: 454451-67-3
• Molecular Weight: 289.331
• Mol File: 454451-67-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (3S)-(8S)-(8aR)-methyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-8-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-(8S)-(8aR)-methyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-8-carboxylic acid methyl ester(454451-67-3)
• EPA Substance Registry System: (3S)-(8S)-(8aR)-methyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-8-carboxylic acid methyl ester(454451-67-3)

Safety Data

• Hazardous Substances Data: 454451-67-3(Hazardous Substances Data)

Upstream product

• 814-68-6 acryloyl chloride 
• 476187-10-7 (Z)-3-((S)-2-Hydroxy-1-phenyl-ethylamino)-but-2-enoic acid methyl ester 
• 20989-17-7 (2S)-2-phenylglycinol 
• 105-45-3 acetoacetic acid methyl ester 
• 120417-13-2 (S)-2-(tert-butyldimethylsilyloxy)-1-phenylethylamine 
• 595582-07-3 1-(2-hydroxy-(1S)-phenyl-ethyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester 

Downstream Products

• 1864003-05-3 (2S,3S)-2-Methyl-piperidine-3-carboxylic acid methyl ester 
• 454451-70-8 (3S)-(8R)-(8aR)-methyl-5-oxo-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-8-carboxylic acid methyl ester 
• 476187-19-6 (1S)-(2S)-(3S)-1-(2-hydroxy-1-phenyl-ethyl)-2-methyl-piperidine-3-carboxylic acid methyl ester 

Relevant articles and documents

Asymmetric synthesis of nitrogen heterocycles by reaction of chiral β-enaminocarbonyl substrates with acrylate derivatives

We have studied the reactivity of β-enaminoesters 1 (R2=OMe) or β-enaminoketone 1 (R2=Me), derived from (S)-phenylglycinol, with activated acrylate derivatives. Substrates 1 (R1=Me) afforded by aza-annulation oxazololactam

A novel stereocontrolled synthesis of enantiopure bicyclic lactams

A study on the reactivity of 3,4-dihydro-2-pyridones 9, derived from (S)-phenylglycinol, toward different bases is presented. Using a catalytic amount of bases, the cis bicyclic lactams were obtained with excellent diastereoselectivities.