595582-07-3Relevant articles and documents
Enantioselective synthesis of indolizidine and quinolizidine derivatives from chiral non-racemic bicyclic lactams
Agami, Claude,Dechoux, Luc,Hebbe, Séverine,Ménard, Cécilia
, p. 5433 - 5438 (2007/10/03)
Chiral non-racemic bicyclic lactams 2b,c, derived from (R)- and (S)-phenylglycinol, were used in the enantioselective synthesis of (-)-lupinine and 5-epitashiromine, respectively. The efficiency of the synthesis relied on the high diastereoselectivities of formation and reduction of compounds 2b,c.
Asymmetric synthesis of nitrogen heterocycles by reaction of chiral β-enaminocarbonyl substrates with acrylate derivatives
Agami, Claude,Dechoux, Luc,Hebbe, Séverine
, p. 2521 - 2523 (2007/10/03)
We have studied the reactivity of β-enaminoesters 1 (R2=OMe) or β-enaminoketone 1 (R2=Me), derived from (S)-phenylglycinol, with activated acrylate derivatives. Substrates 1 (R1=Me) afforded by aza-annulation oxazololactam