4553-62-2 Usage
Description
2-METHYLGLUTARONITRILE, also known as 2-MGN, is an amber liquid that serves as an important chemical intermediate in the synthesis of various compounds. It is a versatile molecule with potential applications across different industries due to its unique chemical properties.
Uses
Used in Chemical Synthesis:
2-METHYLGLUTARONITRILE is used as a chemical intermediate for the synthesis of 1,5-dimethyl-2-piperidone (1,5-DMPD) through a chemoenzymatic process. This application is significant because 1,5-DMPD is a key compound in the production of certain pharmaceuticals and other specialty chemicals.
If there are different applications in different industries, they can be listed separately as follows:
Used in Pharmaceutical Industry:
2-METHYLGLUTARONITRILE is used as a key intermediate for the production of various pharmaceutical compounds, particularly due to its role in the synthesis of 1,5-dimethyl-2-piperidone (1,5-DMPD), which is further utilized in the development of drugs with specific therapeutic applications.
Used in Specialty Chemicals Industry:
2-METHYLGLUTARONITRILE is used as a building block for the creation of specialty chemicals that have unique properties and are used in various applications, such as coatings, adhesives, and polymers. Its versatility as a chemical intermediate makes it valuable in this industry.
Air & Water Reactions
Water soluble.
Reactivity Profile
Nitriles, such as 2-METHYLGLUTARONITRILE, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.
Health Hazard
ACUTE/CHRONIC HAZARDS: 2-METHYLGLUTARONITRILE is readily absorbed through the skin.
Fire Hazard
2-METHYLGLUTARONITRILE is combustible.
Check Digit Verification of cas no
The CAS Registry Mumber 4553-62-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,5,5 and 3 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4553-62:
(6*4)+(5*5)+(4*5)+(3*3)+(2*6)+(1*2)=92
92 % 10 = 2
So 4553-62-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2/c1-6(5-8)3-2-4-7/h6H,2-3H2,1H3
4553-62-2Relevant articles and documents
Efficient nickel-catalyzed hydrocyanation of alkenes using acetone cyanohydrin as a safer cyano source
Nemoto, Koji,Nagafuchi, Tsuyoshi,Tominaga, Ken-ichi,Sato, Kazuhiko
, p. 3199 - 3203 (2016/07/06)
An active nickel catalyst prepared in situ from a Ni(II) compound, phosphine ligand, and zinc powder was found to be an efficient catalyst system for the hydrocyanation of various alkenes using acetone cyanohydrin as a safer cyano source. The combination of NiCl2·6H2O and 1,3-bis(diphenylphosphino)propane was the most efficient catalyst precursor in DMF. Under the optimized conditions, various styrenes, heterocyclic alkenes, and aliphatic alkenes were converted to their corresponding nitriles in excellent yields.
METHOD FOR PRODUCING NITRILE COMPOUNDS FROM ETHYLENICALLY UNSATURATED COMPOUNDS
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Paragraph 0081-0088, (2014/09/16)
The present invention relates to a method for the hydrocyanation of organic ethylenically unsaturated compounds including at least one nitrile function. The invention specifically relates to a method for the hydrocyanation of a hydrocarbon compound including at least one ethylenic unsaturation by a reaction with hydrogen cyanide in a liquid medium and in the presence of a catalyst including a metal element selected from the transition metals and an organophosphorous ligand, the organophosphorous gaud including a compound of general formula (I), where R1 and R2, which are identical or different, are a linear or branched alkyl radical having 1-12 carbon atoms, which can include heteroatoms, or an optionally substituted aromatic or cycloaliphatic radical that can include heteroatoms, wherein the covalent bond between P and R1, and that between P and R2, are P—C bonds.
ORGANOPHOSPHORUS COMPOUNDS, CATALYTIC SYSTEMS COMPRISING SAID COMPOUNDS AND METHOD OF HYDROCYANATION USING SAID CATALYTIC SYSTEMS
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Paragraph 0104-0110, (2013/03/26)
The present invention relates to organophosphorus compounds belonging to the phosphinite-phosphite family, catalytic systems comprising a metallic element forming a complex with said phosphinite-phosphite compounds and methods of hydrocyanation employed in the presence of said catalytic systems.