626-56-2 Usage
Description
3-Methylpiperidine, a colorless liquid with a characteristic odor, is less dense than water and has a flash point less than 141°F. It is toxic by ingestion, inhalation, and skin absorption, and contact may cause severe irritation to skin, eyes, and mucous membranes. As a clear colorless to yellow liquid, it serves as a versatile intermediate in various chemical and pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
3-Methylpiperidine is used as a pharmaceutical intermediate for the synthesis of various compounds with therapeutic potential. It plays a crucial role in the development of drugs targeting different medical conditions.
Used in Anti-hepatitis B Virus Activity:
3-Methylpiperidine is used as a reactant for the synthesis of Phenylpropenamide derivatives, which exhibit anti-hepatitis B virus activity, aiding in the development of treatments for this viral infection.
Used in Chronic Pain Treatment:
As a reactant for the synthesis of CB2 receptor agonists, 3-Methylpiperidine contributes to the development of treatments for chronic pain, offering potential relief for patients suffering from long-term pain conditions.
Used in Anticancer Applications:
3-Methylpiperidine is utilized in the synthesis of aurora kinase inhibitors, which are important in the development of cancer treatments, particularly for solid malignancies.
Used in Organic Synthesis:
3-Methylpiperidine serves as an intermediate in organic synthesis, enabling the creation of a wide range of chemical compounds for various applications, from pharmaceuticals to industrial chemicals.
Used in the Development of Spiroidazolidinone NPC1L1 Inhibitors:
3-Methylpiperidine is used as a reactant in the synthesis of spiroimidazolidinone NPC1L1 inhibitors, which are being investigated for their potential in treating various diseases.
Used in the Synthesis of 1,3,5-Oxadiazinones:
3-Methylpiperidine is also used in the synthesis of 1,3,5-Oxadiazinones, which have potential applications in various fields, including pharmaceuticals and materials science.
Used in the Development of Selective Serotonin 5-HT6 Receptor Antagonists:
3-Methylpiperidine is employed as a reactant for the synthesis of selective serotonin 5-HT6 receptor antagonists, which are being studied for their potential in treating various psychiatric and neurological disorders.
Air & Water Reactions
Highly flammable. Water soluble.
Reactivity Profile
3-METHYLPIPERIDINE neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Generates flammable gaseous hydrogen in combination with strong reducing agents, such as hydrides.
Health Hazard
May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard
Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Purification Methods
Purify it via the hydrochloride (m 172o). The hydrobromide has m 162-163o(from iso-PrOH). [Chapman et al. J Chem Soc 1925 1959, Beilstein 20 III/IV 1499, 20/4 V 100.]
Check Digit Verification of cas no
The CAS Registry Mumber 626-56-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 6 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 626-56:
(5*6)+(4*2)+(3*6)+(2*5)+(1*6)=72
72 % 10 = 2
So 626-56-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H13N/c1-6-3-2-4-7-5-6/h6-7H,2-5H2,1H3/p+1/t6-/m0/s1
626-56-2Relevant articles and documents
Method for preparing piperidine compound by reducing pyridine compound through hydrogen transfer
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Paragraph 0022; 0023; 0024; 0025; 0026, (2021/04/28)
The invention discloses a method for preparing a piperazine compound through a hydrogen transfer reduction of a pyridine compound, belonging to the field of organic synthesis. Under mild conditions, pyridine derivatives are used as raw materials, oxazolidine is used as a hydrogen transfer reagent, and cheap transition metals such as copper, cobalt, silver, palladium and the like are used as catalysts for catalysis of a hydrogen transfer reaction on 1,2,3,4-substitution sites, so a series of hydrogen transfer reduction product piperidine compounds are prepared, wherein the oxazaborolidine is obtained by a reaction of amino acid with a tetrahydrofuran complex of borane. The method has the advantages that product yield is high, reaction conditions are mild, the general applicability of raw materials is good, a hydrogen transfer reagent is cheap and easy to obtain, and good reproducibility can still be shown after quantitative reaction is conudcted. Therefore, the method of the invention provides an effective scheme for the industrial production of other high-value compounds containing the structure in the future.
Powering Artificial Enzymatic Cascades with Electrical Energy
Al-Shameri, Ammar,Apfel, Ulf-Peter,Lauterbach, Lars,Nestl, Bettina M.,Petrich, Marie-Christine,junge Puring, Kai
supporting information, p. 10929 - 10933 (2020/05/04)
We have developed a scalable platform that employs electrolysis for an in vitro synthetic enzymatic cascade in a continuous flow reactor. Both H2 and O2 were produced by electrolysis and transferred through a gas-permeable membrane into the flow system. The membrane enabled the separation of the electrolyte from the biocatalysts in the flow system, where H2 and O2 served as electron mediators for the biocatalysts. We demonstrate the production of methylated N-heterocycles from diamines with up to 99 percent product formation as well as excellent regioselective labeling with stable isotopes. Our platform can be applied for a broad panel of oxidoreductases to exploit electrical energy for the synthesis of fine chemicals.
Cascade Biotransformation to Access 3-Methylpiperidine in Whole Cells
Borlinghaus, Niels,Weinmann, Leonie,Krimpzer, Florian,Scheller, Philipp N.,Al-Shameri, Ammar,Lauterbach, Lars,Coquel, Anne-Sophie,Lattemann, Claus,Hauer, Bernhard,Nestl, Bettina M.
, p. 5738 - 5742 (2019/07/16)
Synthesis of 3-methylpiperidine from 1,5-diamino-2-methylpentane in preparative scale is reported by using recombinant Escherichia coli cells expressing a variant of the diamine oxidase from Rhodococcus erythroprolis and an imine reductase from Streptosporangium roseum. Optimization of process parameters for cultivation and bioconversion led to substantial improvements in the initial laboratory procedure. The transformation of the methyl-substituted diamine substrate to the N-heterocyclic product was successfully scaled-up from shake-flask to a 20 L bioreactor with increased substrate concentrations. Remarkably, we obtained 67 % of 3-methylpiperidine product from 140 g substrate within 52 h.
