462117-87-9Relevant articles and documents
Syntheses of depsipeptide analogues of the insect neuropeptide proctolin.
Scherkenbeck, Juergen,Plant, Andrew,Stieber, Frank,Loesel, Peter,Dyker, Hubert
, p. 1625 - 1628 (2007/10/03)
Four depsipeptide analogues of the insect neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH) have been prepared, containing a single ester linkage between Arg(1) and Tyr(2), Tyr(2) and Leu(3), and between Pro(4) and Thr(5), respectively. A didepsipentapeptide containing an ester linkage between Tyr(2) and Leu(3) and between Pro(4) and Thr(5), has also been prepared. The depsipeptide 4 is the first example of a backbone-modified proctolin analogue which shows full myotropic activity.