669738-91-4Relevant articles and documents
Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation
Bartling, Christian R. O.,Jensen, Thomas M. T.,Henry, Shawna M.,Colliander, Anna L.,Sereikaite, Vita,Wenzler, Marcella,Jain, Palash,Maric, Hans M.,Harps?e, Kasper,Pedersen, S?ren W.,Clemmensen, Louise S.,Haugaard-Kedstr?m, Linda M.,Gloriam, David E.,Ho, Angela,Str?mgaard, Kristian
supporting information, p. 891 - 901 (2021/02/05)
There is an urgent need for novel therapeutic approaches to treat Alzheimer's disease (AD) with the ability to both alleviate the clinical symptoms and halt the progression of the disease. AD is characterized by the accumulation of amyloid-β (Aβ) peptides
Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids
Stuhr-Hansen, Nicolai,Padrah, Shahrokh,Str?mgaard, Kristian
, p. 4149 - 4151 (2015/02/02)
An effective and improved procedure is developed for the synthesis of α-hydroxy carboxylic acids by treatment of the corresponding protonated α-amino acid with tert-butyl nitrite in 1,4-dioxane-water. The amino moiety must be protonated and located α to a carboxylic acid function in order to undergo initial diazotization and successive hydroxylation, since neither β-amino acids nor acid derivatives such as esters and amides undergo hydroxylations. The method is successfully applied for the synthesis of 18 proteinogenic amino acids.
Synthesis of All Nineteen Appropriately Protected Chiral α-Hydroxy Acid Equivalents of the α-Amino Acids for Boc Solid-Phase Depsi-Peptide Synthesis
Deechongkit, Songpon,You, Shu-Li,Kelly, Jeffery W.
, p. 497 - 500 (2007/10/03)
(Equation presented) The preparation of depsi-peptides, amide-to-ester-substituted peptides used to probe the role of hydrogen bonding in protein folding energetics, is accomplished by replacing specific L-α-amino acid residues by their α-hydroxy acid cou