468734-63-6

Basic information

• Product Name: (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carbonitrile
• Synonyms: (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carbonitrile
• CAS NO: 468734-63-6
• Molecular Weight: 419.87
• Mol File: 468734-63-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carbonitrile(468734-63-6)
• EPA Substance Registry System: (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carbonitrile(468734-63-6)

Safety Data

• Hazardous Substances Data: 468734-63-6(Hazardous Substances Data)

Upstream product

• 53360-89-7 2-amino-1-(3-chloro-phenyl)-ethanol 
• 78881-21-7 4-amino-3-methylbenzonitrile 
• 96784-54-2 3-methyl-4-nitrobenzonitrile 
• 468741-04-0 2-(4-iodo-2-methoxy-pyridin-3-yl)-7-methyl-3H-benzimidazole-5-carbonitrile 
• 468741-03-9 3,4-diamino-5-methyl-benzonitrile 
• 468741-02-8 4-amino-3-methyl-5-nitrobenzonitrile 
• 468741-01-7 N-(4-cyano-2-methyl-6-nitro-phenyl)-2,2,2-trifluoro-acetamide 
• 943634-40-0 N-(4-cyano-2-methylphenyl)-2,2,2-trifluoroacetamide 

Downstream Products

• 468741-41-5 (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboxylic acid 
• 468741-39-1 (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboximidic ethyl ester 
• 468739-80-2 (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carboxylic acid amide 
• 468739-76-6 (+/-)-2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzimidazole-5-carbaldehyde 
• 468739-75-5 (+/-)-4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-3-[6-(4,5-dihydro-thiazol-2-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridin-2-one 

Relevant articles and documents

Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile

A series of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) were examined in which the pendant imidazole moiety was replaced to improve selectivity for IGF-1R inhibition over cytochrome P450 (CYP). Synthesis and SAR of these compounds is presented.