470715-52-7Relevant articles and documents
Design, synthesis, and in vitro biological activity of benzimidazole based Factor Xa inhibitors
Zhao, Zuchun,Arnaiz, Damian O.,Griedel, Brian,Sakata, Steven,Dallas, Jerry L.,Whitlow, Marc,Trinh, Lan,Post, Joseph,Liang, Amy,Morrissey, Michael M.,Shaw, Kenneth J.
, p. 963 - 966 (2007/10/03)
Inhibitors based on the benzimidazole scaffold showed subnanomolar potency against Factor Xa with 500-1000-fold selectivity against thrombin and 50-100-fold selectivity against trypsin. The 2-substituent on the benzimidazole ring had a strong impact on th