484691-32-9

Basic information

• Product Name: 6-ethoxycarbonyl-2-(4-nitrophenyl)-8H-imidazolo[1,2-a]pyrimid-5-one
• CAS NO: 484691-32-9
• Molecular Weight: 328.284
• Mol File: 484691-32-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-ethoxycarbonyl-2-(4-nitrophenyl)-8H-imidazolo[1,2-a]pyrimid-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-ethoxycarbonyl-2-(4-nitrophenyl)-8H-imidazolo[1,2-a]pyrimid-5-one(484691-32-9)
• EPA Substance Registry System: 6-ethoxycarbonyl-2-(4-nitrophenyl)-8H-imidazolo[1,2-a]pyrimid-5-one(484691-32-9)

Safety Data

• Hazardous Substances Data: 484691-32-9(Hazardous Substances Data)

Upstream product

• 15400-53-0 ethyl 2-amino-4-hydroxypyrimidine-5-carboxylate 
• 99-81-0 4-Nitrophenacyl bromide 

Downstream Products

• 484691-34-1 6-ethoxycarbonyl-8-(2-fluorobenzyl)-2-(4-nitrophenyl)imidazolo[1,2-a]pyrimid-5-one 
• 484691-35-2 6-(3-penthoxycarbonyl)-8-(2-fluorobenzyl)-2-(4-nitrophenyl)imidazolo[1,2-a]pyrimid-5-one 
• 484691-36-3 2-(4-butyrylamino-phenyl)-8-(2-fluoro-benzyl)-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 484691-37-4 2-(4-butyrylamino-phenyl)-8-(2-fluoro-benzyl)-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid 1-ethyl-propyl ester 

Relevant articles and documents

Synthesis and initial structure-activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.

SAR studies of 2-arylimidazolo[1,2-a]pyrimid-5-ones 10a-m, which were derived from initial lead 3a, resulted in the discovery of a series of potent nonpeptide human GnRH receptor antagonists. Compounds with good potency (e.g., 10e, K(i)=7.5 nM) were prepa