484691-35-2Relevant articles and documents
Synthesis and initial structure-activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.
Wilcoxen, Keith M,Zhu, Yun Fei,Connors, Patrick J,Saunders, John,Gross, Timothy D,Gao, Yinghong,Reinhart, Greg J,Struthers, R Scott,Chen, Chen
, p. 2179 - 2183 (2007/10/03)
SAR studies of 2-arylimidazolo[1,2-a]pyrimid-5-ones 10a-m, which were derived from initial lead 3a, resulted in the discovery of a series of potent nonpeptide human GnRH receptor antagonists. Compounds with good potency (e.g., 10e, K(i)=7.5 nM) were prepa