5021-45-4

Basic information

• Product Name: CHEMBRDG-BB 5128501
• Synonyms: CHEMBRDG-BB 5128501;2-(4-Bromophenyl)quinoxaline;2-(4-bromophenyl)quinoxaline(SALTDATA: FREE);Quinoxaline, 2-(4-bromophenyl)-
• CAS NO: 5021-45-4
• Molecular Formula: C₁₄H₉BrN₂
• Molecular Weight: 285.14
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Quinoxalines
• Mol File: 5021-45-4.mol
• Article Data: 67

Chemical Properties

• Melting Point: 133-138 °C
• Boiling Point: 408.2°C at 760 mmHg
• Flash Point: 200.7°C
• Appearance: /
• Density: 1.489g/cm³
• Vapor Pressure: 1.68E-06mmHg at 25°C
• Refractive Index: 1.682
• PKA: 0.06±0.30(Predicted)
• CAS DataBase Reference: CHEMBRDG-BB 5128501(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 5128501(5021-45-4)
• EPA Substance Registry System: CHEMBRDG-BB 5128501(5021-45-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 5021-45-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H9BrN2/c15-11-7-5-10(6-8-11)14-9-16-12-3-1-2-4-13(12)17-14/h1-9H

Upstream product

• 1128-10-5 1,2-dicarbomethoxycyclobutene 
• 117836-46-1 2-(4-Bromo-phenyl)-1-phenyl-1,1a-dihydro-3,7b-diaza-cyclopropa[a]naphthalene 
• 25233-81-2 1-(4-bromophenyl)-4-phenyl-2-butene-1,4-dione 
• 95-54-5 1,2-diamino-benzene 
• 149281-69-6 Z-2-p-bromobenzoylmethyl-5-phenyl-2,3-dihydro-3-furanone 
• 5021-38-5 3-(4-bromo-phenyl)-1,2-dihydro-quinoxaline 
• 3320-86-3 2-nitrophenyl isocyanate 
• 99-73-0 para-bromophenacyl bromide 
• 3343-45-1 4-bromo-2-hydroxyacetophenone 
• 875289-82-0 2,4-dinitro-benzenesulfonic acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester 
• 1448-87-9 2-chloroquinoxaline 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 27200-79-9 p-bromophenylacetaldehyde 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 1221687-23-5 (R)-2-(4-bromophenyl)-1,2,3,4-tetrahydroquinoxaline 
• 1262801-92-2 2-(4-bromo-2-nitrophenyl)quinoxaline 
• 1327154-14-2 2-(4-bromophenyl)-1,2,3,4-tetrahydroquinoxaline 
• 1420295-64-2 2-(4-bromophenyl)-3-(dimethoxymethyl)quinoxaline 
• 1444302-51-5 2-(4-bromo-2-fluorophenyl)quinoxaline 

Relevant articles and documents

Synthesis of polycyclic 3,3′-spirooxindoles and some new 2-arylquinoxalines from (E/Z)- 1-(2-oxo-2-arylethylidene)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-ones

A facile protocol to access a novel series of spirocyclodiazepines from cyclocondensation of 1-(2-oxo-2-arylethylidene)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-ones (derived from 5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinolone-1,2(4H)?dione) with ethane-1,2-diamines and benzene-1,2-diamines, generates polycyclic spirooxindoles and unexpectedly produces 2-arylquinoxalines instead of spiro[indole-1,5-benzodiazepines], respectively, in the presence of p-TSA as an efficient catalyst in a green solvent.

Mechanically induced transition metal free C(sp2)-H arylation of quinoxalin(on)es with diaryliodonium salts and piezoelectric BaTiO3

A transition metal free mechanically induced C(sp2)-H arylation of quinoxalin(on)es is described. In this study, diaryliodonium salts generate aryl radical by planetary ball milling, with the assist of piezoelectric material BaTiO3. A broad range of functional groups are tolerated to give products in moderate to good yields via radical mechanism.

Mechanochemical Synthesis of 2-Arylquinoxalines and 3-Arylquinoxalin-2(1H)-ones via Aryldiazonium Salts

A green synthesis strategy of 2-arylquinoxalines and 3-arylquinoxalin-2(1H)-ones via ball milling, which could avoid copious solvent waste, was accomplished in this work. Aryl radicals were produced from aryldiazonium salts by using a solvent-free or catalyst-free single electron transfer process induced by mechanical force, affording a series of 2-arylquinoxalines and 3-arylquinoxalin-2(1H)-ones with 28%–85 yield. (Figure presented.).