3343-45-1

Basic information

• Product Name: 1-(4-BROMOPHENYL)-2-HYDROXYETHAN-1-ONE
• Synonyms: (4-BROMOBENZOYL)METHANOL;1-(4-BROMOPHENYL)-2-HYDROXY-1-ETHANONE;1-(4-BROMOPHENYL)-2-HYDROXYETHAN-1-ONE;2-HYDROXY-1-(4-BROMOPHENYL)ETHANONE;1-(4-Bromophenyl)-2-hydroxyethane-1-one;1-(4-BroMophenyl)-2-hydroxyethanone
• CAS NO: 3343-45-1
• Molecular Formula: C₈H₇BrO₂
• Molecular Weight: 215.04
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Adehydes, Acetals & Ketones;Bromine Compounds
• Mol File: 3343-45-1.mol
• Article Data: 53

Chemical Properties

• Melting Point: 137 °C
• Boiling Point: 321.5 °C at 760 mmHg
• Flash Point: 148.3 °C
• Appearance: /
• Density: 1.597 g/cm³
• Vapor Pressure: 0.000122mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(4-BROMOPHENYL)-2-HYDROXYETHAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMOPHENYL)-2-HYDROXYETHAN-1-ONE(3343-45-1)
• EPA Substance Registry System: 1-(4-BROMOPHENYL)-2-HYDROXYETHAN-1-ONE(3343-45-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 3343-45-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Canadian Journal of Chemistry, 30, p. 454, 1952 DOI: 10.1139/v52-054Tetrahedron Letters, 22, p. 1283, 1981 DOI: 10.1016/S0040-4039(01)90297-7

InChI:InChI=1/C8H7BrO2/c9-7-3-1-6(2-4-7)8(11)5-10/h1-4,10H,5H2

Upstream product

• 116956-20-8 [2-bromo-1-(4-bromo-phenyl)-ethylidenamino]-guanidine; hydrobromide 
• 99-90-1 para-bromoacetophenone 
• 97006-84-3 [2-(4-Bromo-phenyl)-1,2-dihydroxy-ethyl]-phosphonic acid diethyl ester 
• 74087-85-7 3,3-dimethyldioxirane 
• 5391-88-8 1-(4-bromophenyl)ethanol 
• 32017-76-8 (+/-)-2-(4-bromophenyl)oxirane 
• 7500-37-0 2-(4-bromophenyl)-2-oxoethyl acetate 
• 875289-82-0 2,4-dinitro-benzenesulfonic acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester 
• 99-73-0 para-bromophenacyl bromide 
• 4209-02-3 1-(4-bromophenyl)-2-chloroethan-1-one 
• 619-41-0 4-(bromoacetyl)toluene 
• 60585-76-4 diethyl (Ε)-2-(4-bromophenyl)vinylphosphonate 
• 1122-91-4 4-bromo-benzaldehyde 
• 517-25-9 trinitromethane 

Downstream Products

• 99548-60-4 1-(4-bromophenyl)-2,3-dihydroxypropan-1-one 
• 13569-96-5 4-(4-bromophenyl)-1H-imidazole 
• 90766-28-2 p-bromophenacyl chloroacetate 
• 88690-88-4 2-(4-Bromphenyl)-2-ethoxyoxiran 
• 92093-23-7 (R)-(-)-1-(4-bromophenyl)-1,2-ethanediol 
• 20034-54-2 4-(4-bromophenyl)-2-phenyl-2H-[1,2,3]triazole 
• 850089-99-5 6-(4-bromophenyl)-3-(2-pyridyl)-1,2,4-triazine 
• 143526-49-2 2-(4-bromophenyl)pyrazine 
• 160332-70-7 (S)-(+)-1-(4-bromophenyl)-1,2-ethanediol 
• 88690-89-5 meso-2,5-Bis(4-bromphenyl)-2,5-diethoxy-1,4-dioxan 
• 10557-20-7 1-(4-bromophenyl)-1,2-propanedione 
• 5021-45-4 2-(4-bromophenyl)quinoxaline 
• 1226985-52-9 C₁₄H₂₁BrN₂O 
• 1354546-67-0 1-(4-bromophenyl)-2-(tetrahydro-2H-pyran-2-yloxy)ethanone 

Relevant articles and documents

Reactions of cephalosporin sulphones 1. Rearrangement of the β-lactam ring to a triazole derivative

The 7β-amino-cephalosporin sulphones, generated in situ from the appropriate 7β-tBoc-amino derivative and diazotized in a one-pot reaction in aq. HClO4 - MeOH - NaNO2, rearrange exclusively to the triazoles 5 in a multistep reaction.

Chiral Bidentate Phosphoramidite-Pd Catalyzed Asymmetric Decarboxylative Dipolar Cycloaddition for Multistereogenic Tetrahydrofurans with Cyclic N-Sulfonyl Ketimine Moieties

An asymmetric [3 + 2] cycloaddition of vinyl ethylenecarbonates (VECs) and (E)-3-arylvinyl substituted benzo[d] isothiazole 1,1-dioxides has been developed using the Pd complex of a bidentate phosphoramidite (Me-BIPAM) as the catalyst, providing a wide variety of chiral multistereogenic vinyltetrahydrofurans in good yields with excellent diastereo- and enantioselectivities (up to >20:1 dr, 99% ee).

Aerobic Direct Dioxygenation of Terminal/Internal Alkynes to α-Hydroxyketones by an Fe Porphyrin Catalyst

We herein report a new synthetic method for the preparation of α-hydroxyketones by the dioxygenation of alkynes. The reaction proceeds at room temperature under the action of Fe porphyrin and pinacolborane under air as a green oxidant to produce α-hydroxyketones. The mild reaction conditions allow chemoselective oxidation with functional group tolerance. Terminal alkynes in addition to internal alkynes are applicable, affording unsymmetrical α-hydroxyketones that are difficult to obtain by any reported dioxygenation of unsaturated C?C bonds.