50651-39-3Relevant articles and documents
Synthesis method of high-purity 2 - nitro -4-aminoanisole
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Paragraph 0057-0062, (2021/11/19)
The invention discloses a synthesis method of high-purity 2 -nitro -4-aminoanisole, wherein 2 - nitro -4-n-aminoanisole is synthesized through an assembly line. The assembly line comprises a reaction device, a discharging device and a cleaning device. The method comprises the following steps: A, feeding reaction raw materials into a reaction device for reaction. B, Use clear bottom device to carry out the stirring to phase transfer catalyst and reaction raw materials. C, Use the cleaning device to clean the bottom of reation kettle. D, The extrusion device is used to clean and blow the cleaning device and the bottom cleaning device, and the catalyst and the reaction raw material are pushed up and down. E: The extraction bucket is used to extract the product in the reaction liquid and the extracted reaction is continued to return to the reaction kettle. F, Use the discharging device to make the reaction all discharge. G, Wash the reaction liquid with the cleaning device, obtain the finished product.
A 2 - amino - 4 - acetyl amino methyl ether synthesis method (by machine translation)
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, (2018/05/01)
The invention discloses a 2 - amino - 4 - acetyl amino methyl ether synthesis method. The synthetic method comprises the following steps: (1) in the presence of a catalyst A, to nitroanisole with hydrogen by a catalytic hydrogenation reduction reaction to obtain the amino anisole; (2) P a the fuel to the acetylation reaction acetyl amino anisole; (3) to the acetaminophen a fuel for nitration reaction to obtain the 2 - nitro - 4 - acetamido anisole; (4) in the presence of a catalyst B, 2 - nitro - 4 - acetyl amino methyl ether with hydrogen by secondary catalytic hydrogenation reduction reaction. This invention adopts the first acylation, re-nitration, reduction method for synthesis of 2 - amino - 4 - acetyl amino methyl ether, avoids the traditional directional acylate raw material is easy to oxidation in the process, a plurality of side reaction, the product is hard to separate, the problem of low purity, the method of the invention the synthetic product purity can be up to 99.5% -99.8%. (by machine translation)
Regioselective nitration of anilines with Fe(NO3)3·9H2O as a promoter and a nitro source
Gao, Yang,Mao, Yuanyou,Zhang, Biwei,Zhan, Yingying,Huo, Yanping
supporting information, p. 3881 - 3884 (2018/06/08)
An efficient Fe(NO3)3·9H2O promoted ortho-nitration reaction of aniline derivatives has been developed. This reaction may go through a nitrogen dioxide radical (NO2) intermediate, which is generated by the thermal decomposition of iron(iii) nitrate. The practicality of the present method using nontoxic and inexpensive iron reagents has been shown by the broad substrate scope and applications.