577-72-0

Basic information

• Product Name: 4-METHOXY-3-NITROANILINE
• Synonyms: Benzenamine, 4-methoxy-3-nitro-;3-NITRO-P-ANISIDINE;4-METHOXY-3-NITROANILINE;3-Nitro-p-anisidine (NH2=1);3-Nitro-4-methoxybenzene-1-amine;4-METHOXY-3-NITROANI;4-Amino-2-nitroanisole, 5-Amino-2-methoxynitrobenzene;Esomeprazole Impurity 10
• CAS NO: 577-72-0
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.15
• EINECS: 202-547-2
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;API intermediates
• Mol File: 577-72-0.mol
• Article Data: 24

Chemical Properties

• Melting Point: 46-47 °C
• Boiling Point: 356.9 °C at 760 mmHg
• Flash Point: 169.7 °C
• Appearance: /
• Density: 1.318 g/cm³
• Vapor Pressure: 2.82E-05mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly)
• PKA: 3.33±0.10(Predicted)
• CAS DataBase Reference: 4-METHOXY-3-NITROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-3-NITROANILINE(577-72-0)
• EPA Substance Registry System: 4-METHOXY-3-NITROANILINE(577-72-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 577-72-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H8N2O3/c1-12-7-3-2-5(8)4-6(7)9(10)11/h2-4H,8H2,1H3

Upstream product

• 119-27-7 2,4-dinitroanisole 
• 50651-39-3 2-nitro-4-acetylamino-anisole 
• 51-66-1 4-methoxyacetanilide 
• 104-94-9 4-methoxy-aniline 
• 121-44-8 triethylamine 
• 89-41-8 4-methoxy-3-nitrobenzoic acid 
• 7664-93-9 sulfuric acid 
• 67-56-1 methanol 
• 364-76-1 4-Fluoro-3-nitroaniline 
• 124-41-4 sodium methylate 
• 155863-54-0 p-methoxyanilinium nitrate 
• 119-34-6 4-amino-2-nitrophenol 
• 74-88-4 methyl iodide 
• 97-00-7 1-chloro-2,4-dinitro-benzene 

Downstream Products

• 29906-33-0 4-diazo-2-nitrophenol 
• 91-23-6 2-Nitroanisole 
• 52692-09-8 4-iodo-2-nitroanisole 
• 88-75-5 2-hydroxynitrobenzene 
• 50651-39-3 2-nitro-4-acetylamino-anisole 
• 50516-77-3 N-(3-amino-4-methoxyphenyl)-benzamide 
• 228425-51-2 N-(4-methoxy-3-nitro-phenyl)-N'-phenyl-urea 
• 77600-77-2 propionic acid-(4-methoxy-3-nitro-anilide) 
• 6623-91-2 6-methoxy-5-nitroquinoline 
• 855760-37-1 6-methoxy-7-nitro-quinoline 
• 89974-93-6 N-(3-nitro-4-methoxyphenyl)antranilic acid 
• 23745-12-2 Cyclopropanecarboxylic acid (4-methoxy-3-nitro-phenyl)-amide 
• 143032-35-3 C-Chloro-N-(4-methoxy-3-nitro-phenyl)-methanesulfonamide 
• 89-21-4 4-chloro-2-nitroanisole 

Relevant articles and documents

Design, synthesis, and biological evaluation of quinazoline derivatives as dual HDAC1 and HDAC6 inhibitors for the treatment of cancer

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Preparation method for osimertinib mesylate

The invention discloses a preparation method for osimertinib mesylate. The chemical name of osimertinib mesylate is N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide mesylate (AZD9291), and the chemical formula is C28H33N7O2.CH4O3S. The process of the preparation technique of the preparation method is simple, materials areeasy to obtain, and the preparation method is cost-efficient and environment-friendly, can help realize industrialization, can promote the economic and technological development of osimertinib activeingredients, reduces production cost, and is suitable for mass production.

Method for synthesizing 3-amino-4-methoxy acetanilide by binary alloy catalysis

The invention relates to a method for synthesizing 3-amino-4-methoxy acetanilide by catalytically hydrogenising 3-nitro-4-methoxy acetanilide (NMA) with a nano copper/ silver binary alloy catalyst, and belongs to the field of nano catalysis. The reaction