50690-08-9

Basic information

• Product Name: Ethanone, 2-chloro-1-(3,4-dimethylphenyl)- (9CI)
• Synonyms: Ethanone, 2-chloro-1-(3,4-dimethylphenyl)- (9CI);2-chloro-1-(3,4-dimethylphenyl)ethanone(SALTDATA: FREE);Ethanone,2-chloro-1-(3,4-diMethylphenyl)-
• CAS NO: 50690-08-9
• Molecular Formula: C₁₀H₁₁ClO
• Molecular Weight: 182.64674
• Product Categories: ACETYLHALIDE
• Mol File: 50690-08-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 287.8 °C at 760 mmHg
• Flash Point: 146.2 °C
• Appearance: /
• Density: 1.107 g/cm³
• Vapor Pressure: 0.00244mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: Ethanone, 2-chloro-1-(3,4-dimethylphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-chloro-1-(3,4-dimethylphenyl)- (9CI)(50690-08-9)
• EPA Substance Registry System: Ethanone, 2-chloro-1-(3,4-dimethylphenyl)- (9CI)(50690-08-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 50690-08-9(Hazardous Substances Data)

Usage

General Description

Ethanone, 2-chloro-1-(3,4-dimethylphenyl)- (9CI) is a chemical compound with the molecular formula C10H11ClO. It is also known by its common name, 2-chloroacetophenone. Ethanone, 2-chloro-1-(3,4-dimethylphenyl)- (9CI) is a colorless to pale yellow liquid with a pungent odor. It is commonly used in the production of pharmaceuticals, as a flavoring agent, and as an intermediate in organic synthesis. It is also used in chemical warfare agents and as a tear gas due to its irritant properties. However, it is important to handle this compound with caution as it can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C10H11ClO/c1-7-3-4-9(5-8(7)2)10(12)6-11/h3-5H,6H2,1-2H3

Upstream product

• 95-47-6 o-xylene 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 65782-62-9 2-benzothiazol-2-ylsulfanyl-1-(3,4-dimethyl-phenyl)-ethanone 
• 93729-32-9 N-[2-(3,4-dimethyl-phenyl)-2-oxo-ethyl]-phthalimide 
• 113813-43-7 Phosphoric acid 1-(3,4-dimethyl-phenyl)-vinyl ester dimethyl ester 
• 87198-54-7 [2-Chloro-1-(3,4-dimethyl-phenyl)-1-hydroxy-ethyl]-phosphonic acid dimethyl ester 
• 3637-01-2 3,4-dimethylacetophenone 
• 113813-45-9 Phosphoric acid 1-(3,4-dimethyl-phenyl)-vinyl ester diethyl ester 
• 113813-52-8 [2-Chloro-1-(3,4-dimethyl-phenyl)-1-hydroxy-ethyl]-phosphonic acid diethyl ester 
• 3347-99-7 4-methyl isophthalic acid 
• 13145-57-8 1,2-Bis-(3,4-dimethylbenzoyl)-ethan 

Relevant articles and documents

A pyridazinone compounds and its synthetic method (by machine translation)

The invention relates to a pyridazinone compounds and its synthetic method, said compound of the general formula as follows: Wherein R1 As the C1 - C4 alkyl or halogen; R2 As the C1 - C4 alkyl or halogen; R3 Straight chain aliphatic amine or cyclic amine or c mercapto or aromatic methoxy; R4 Is halogen or c mercapto; at the time of preparation, first halo acetyl halogen reaction with benzene process fu - grams of synthetic α - halogenated acetophenone, with 4, 5 - dichloro - 3 (2 H) - pyridazinone substitution reaction synthetic intermediates, the generated intermediate under the catalysis of the alkaline reagent, with nucleophiles such as amines or cyclic aliphatic amine or propanethiol undergo the substitution reaction synthesis pyridazinone compounds. Compared with the prior art, the present invention the entire process is simple, and good repeatability, and is simple, wide range of application, it has very good application prospect. (by machine translation)

Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin

A series of α-triazolyl chalcones were efficiently synthesized. Most of the prepared compounds showed effective antibacterial and antifungal activities. Noticeably, α-triazolyl derivative 9a exhibited low MIC value of 4 μg/mL against MRSA and Micrococcus luteus, which was comparable or even superior to reference drugs. The further research revealed that compound 9a could effectively intercalate into Calf Thymus DNA to form 9a-DNA complex which might block DNA replication to exert their powerful antimicrobial activities. Competitive interactions between 9a and metal ions to Human Serum Albumin (HSA) suggested the participation of Fe3+, K+ and Mg 2+ ions in 9a-HSA system could increase the concentration of free 9a, shorten its storage time and half-life in the blood, thus improving its antimicrobial efficacy.

Antimony(V) chloride-benzyltriethylammonium chloride complex as an efficient catalyst for friedel-crafts acylation reactions

A novel catalytic system, the complex of antimony(V) chloride (SbCl 5) and benzyltriethylammonium chloride (TEBA), C6H 5CH2NEt3(SbCl5)2Cl complex, is described for Friedel-Crafts acylation reactions of aromatics with acyl and sulfonyl chlorides. The catalyst has a number of useful characteristics, such as ready access, minimal toxicity, reusability, insensitivity to atmosphere and moisture, rapid acylation with high yield, and ease of operation.