93729-32-9

Basic information

• Product Name: N-[2-(3,4-dimethyl-phenyl)-2-oxo-ethyl]-phthalimide
• CAS NO: 93729-32-9
• Molecular Weight: 293.322
• Mol File: 93729-32-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[2-(3,4-dimethyl-phenyl)-2-oxo-ethyl]-phthalimide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(3,4-dimethyl-phenyl)-2-oxo-ethyl]-phthalimide(93729-32-9)
• EPA Substance Registry System: N-[2-(3,4-dimethyl-phenyl)-2-oxo-ethyl]-phthalimide(93729-32-9)

Safety Data

• Hazardous Substances Data: 93729-32-9(Hazardous Substances Data)

Upstream product

• 50690-08-9 2-chloro-1-(3,4-dimethyl-phenyl)-ethanone 
• 1074-82-4 potassium phtalimide 

Relevant articles and documents

New Anticancer Agents: Synthesis of 1,2-Dihydropyridopyrizines (1-Deaza-7,8-dihydropteridines)

Reaction of α-aminoacetophenone oximes (2) with ethyl 6-amino-4-chloro-5-nitropyridine-2-carbamate (1) gave ethyl 6-amino-5-nitro-4-pyridine-2-carbamate oximes (3), which were hydrolyzed under acidic conditions to give the corresponding ketones (4).Related pyridines substituted with keto side chain were prepared from 1 and 1,3-diaminopropanone oximes and by oxidation of the side-chain hydroxy group of ethyl 6-amino-4-amino>-5-nitropyridine-7-carbamates (6).Catalytic hydrogenation of the nitro group of 4 over Raney nickel in a large volume of ethanol gave the 1-deaza-7,8-dihydropteridines (7).Several of the oximes 3 were successfully hydrogenated to give 7 directly.The resulting 1-deaza-7,8-dihydropteridines showed potent cytotoxicity against cultured L1210 cells and significant anticancer activity against lymphocytic leukemia P-388 in mice.THese biological activities are attributed to the accumulation of cells at mitosis.