518021-15-3

Basic information

• Product Name: 2-allyl-2-(2-iodo-3-methylbenzyl)malonic acid dimethyl ester
• Synonyms: 2-allyl-2-(2-iodo-3-methylbenzyl)malonic acid dimethyl ester
• CAS NO: 518021-15-3
• Molecular Weight: 402.229
• Mol File: 518021-15-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-allyl-2-(2-iodo-3-methylbenzyl)malonic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-allyl-2-(2-iodo-3-methylbenzyl)malonic acid dimethyl ester(518021-15-3)
• EPA Substance Registry System: 2-allyl-2-(2-iodo-3-methylbenzyl)malonic acid dimethyl ester(518021-15-3)

Safety Data

• Hazardous Substances Data: 518021-15-3(Hazardous Substances Data)

Upstream product

• 108-59-8 malonic acid dimethyl ester 
• 100959-88-4 (2-iodo-3-methylphenyl)methanol 
• 108078-14-4 2-iodo-3-methylbenzoic acid 
• 4389-45-1 3-methylantranilic acid 
• 40637-56-7 dimethyl allylmalonate 
• 99848-41-6 1-(bromomethyl)-2-iodo-3-methylbenzene 

Downstream Products

• 518021-24-4 C₁₆H₁₉O₄ 
• 518021-16-4 2-allyl-2-(3-methylbenzyl)malonic acid dimethyl ester 
• 49769-78-0 2-benzyl-malonic acid dimethyl ester 

Relevant articles and documents

Quantitating the effect of an ortho substituent on cyclization and intramolecular hydrogen-transfer reactions of aryl radicals

Reduction of allyl 2-iodobenzyl malonates with triphenyltin hydrides generates aryl radicals that partition between 6-exo cyclization, 7-endo cyclization, and 1,5-hydrogen atom transfer. Rate constants for all of these processes are high (> 108 M-1 s-1), and the rates are only marginally reduced (33%) by the introduction of methyl group ortho to the reacting radical.