52884-95-4

Basic information

• Product Name: 2-oxo-N-phenylhexanamide
• Synonyms: 2-Oxo-N-phenylhexanamide; hexanamide, 2-oxo-N-phenyl-
• CAS NO: 52884-95-4
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.253
• Mol File: 52884-95-4.mol
• Article Data: 7

Chemical Properties

• Density: 1.105g/cm³
• Refractive Index: 1.549
• CAS DataBase Reference: 2-oxo-N-phenylhexanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxo-N-phenylhexanamide(52884-95-4)
• EPA Substance Registry System: 2-oxo-N-phenylhexanamide(52884-95-4)

Safety Data

• Hazardous Substances Data: 52884-95-4(Hazardous Substances Data)

Usage

General Description

2-oxo-N-phenylhexanamide is a chemical compound with the molecular formula C12H15NO2. It is a white to off-white powder that is soluble in organic solvents. 2-oxo-N-phenylhexanamide is used in the pharmaceutical industry as a precursor for the synthesis of various pharmaceutical drugs. It is also used in research and development for the study of its biological and pharmacological properties. 2-oxo-N-phenylhexanamide is known to have certain psychoactive and analgesic properties, and it is being investigated for its potential use in the treatment of pain and mood disorders. However, it is important to handle this compound with care due to its potential health hazards, and it should only be used by trained professionals in a controlled laboratory setting.

Upstream product

• 136617-36-2 2-Benzotriazol-1-yl-2-carbazol-9-yl-hexanoic acid phenylamide 
• 203132-02-9 2-Benzotriazol-1-yl-2-methylsulfanyl-hexanoic acid phenylamide 
• 203131-81-1 1-(benzotriazol-1-yl)pent-1-yl methyl thioether 
• 132724-55-1 1-(benzotriazol-1-yl)-1-(carbazol-9-yl)-pentane 
• 103-71-9 phenyl isocyanate 
• 62-53-3 aniline 
• 693-02-7 hex-1-yne 
• 109-72-8 n-butyllithium 
• 13797-22-3 methyl N-phenyloxamate 
• 201230-82-2 carbon monoxide 
• 94266-06-5 diethyl 4-butyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 444343-55-9 butyltrifluoro-λ⁴-borane potassium salt 

Relevant articles and documents

Manganese(III)-Promoted Double Carbonylation of Anilines Toward α-Ketoamides Synthesis

Employing anilines as nucleophiles in double carbonylation is a longstanding challenge. In this communication, a Mn(III)-promoted double carbonylation of alkylborates or Hantzsch esters with anilines toward the synthesis of α-ketoamides has been developed. By using easily available potassium alkyltrifluoroborates or Hantzsch esters as the starting material, and cheap and non-toxic Mn(OAc)3 ? 2H2O as the promotor, a broad range of alkyl α-ketoamide derivatives were synthesized in moderate to good yields with excellent selectivity. (Figure presented.).

Visible-light initiated copper(i)-catalysed oxidative C-N coupling of anilines with terminal alkynes: One-step synthesis of α-ketoamides

Development of C-N coupling processes is fundamentally important and challenging for the synthesis of biologically active molecules and drugs. Herein, we report a highly atom efficient green process for the synthesis of α-ketoamides via visible-light induced copper(i) chloride catalysed direct oxidative Csp-N coupling reactions using commercially available alkynes and anilines at room temperature without the use of hazardous chemicals and harsh reaction conditions. Forty-seven examples are presented using a broad range of substrates including electron deficient anilines and various terminal alkynes. The current photochemical process is able to achieve epoxide hydrolase inhibitors in one step with high yield (92-95%). This transformation is highly efficient and highly selective for the synthesis of α-ketoamides. This journal is

Syntheses of Dialkyl and Functionalized Ketones via 1-(Benzotriazol-1-yl)alkyl Methyl Thioethers

Benzotriazol-1-ylmethyl methyl thioether (1), after easy deprotonation by BuLi, reacted with alkyl halides to afford 1-(benzotriazol-1-yl)alkyl methyl thioethers 2 in good yields. The utility of compounds 2 as alkanoyl anion equivalents was demonstrated by the reactions of their anions with alkyl halides, aldehydes, ketones, esters, and phenyl isocyanate: the products were readily hydrolyzed to α-functionalized ketones in dilute aqueous acid.