94266-06-5

Basic information

• Product Name: diethyl 4-butyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate
• Synonyms: diethyl 4-butyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate;2,6-Dimethyl-4-butyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester;4-Butyl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester;4-Butyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
• CAS NO: 94266-06-5
• Molecular Formula: C₁₇H₂₇NO₄
• Molecular Weight: 309.40058
• EINECS: 304-412-4
• Mol File: 94266-06-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 403.2°Cat760mmHg
• Flash Point: 197.7°C
• Appearance: /
• Density: 1.031g/cm³
• Vapor Pressure: 1.04E-06mmHg at 25°C
• Refractive Index: 1.477
• CAS DataBase Reference: diethyl 4-butyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 4-butyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate(94266-06-5)
• EPA Substance Registry System: diethyl 4-butyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate(94266-06-5)

Safety Data

• Hazardous Substances Data: 94266-06-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H27NO4/c1-6-9-10-13-14(16(19)21-7-2)11(4)18-12(5)15(13)17(20)22-8-3/h13,18H,6-10H2,1-5H3

Upstream product

• 110-62-3 pentanal 
• 141-97-9 ethyl acetoacetate 
• 506-87-6 ammonium carbonate 
• 631-61-8 ammonium acetate 
• 123-72-8 butyraldehyde 
• 626-34-6 ethyl 3-aminobut-2-enoate 

Downstream Products

• 52884-95-4 2-oxo-N-phenylhexanamide 

Relevant articles and documents

Synthesis and anticonvulsant activity of some 1,4-dihydropyridine derivatives

A series of asymmetrical 4-alkyl/aryl-2,6-dimethyl-3-N-(aryl/heteroaryl)-carbamoyl-5-ethoxycarbonyl-1, 4-dihydropyridines 3a-d and symmetrical 4-alkyl/aryl-2,6-dimethyl-3,5-bis-(ethoxycarbonyl)-1,4-dihydropyridines 4a and 4b have been prepared by the condensation of various benzaldehydes, ethylacetoacetate, 2-aminopyridine or p-toludine in ethanol (Hantzch method). The structures of all the synthesized 1,4-dihydropyridine derivatives have been confirmed by spectral data (IR,1H NMR) and elemental analysis. Compounds 3a-c, 4a and 4b (10 mg/kg) have been evaluated for their anticonvulsant effect against pentylenetetrazole- induced convulsions with phenytoin (4 mg/kg) as the standard. The anticonvulsant potential of the newly synthesized compounds have been assessed on the basis of increase in latency (onset time) to induce convulsions; decrease in number of convulsions and increase in latency of death compared to control and standard.

Synthesis of diethyl 4-substituted-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates as a new series of inhibitors against yeast α-glucosidase

1,4-Dihydropyridine-3,5-dicarboxylate derivatives (1-25) were synthesized in high yields via Hantzsch reaction and evaluated for their α-glucosidase inhibitory activity. Compounds 1, 2, 6-8, 11, 13-15, and 23-25 showed a potent inhibitory activity against yeast α-glucosidase with IC50 values in the range of 35.0-273.7 μM, when compared with the standard drug acarbose (IC50 = 937 ± 1.60 μM). Their structures were characterized by different spectroscopic techniques. The kinetics, selectivity, and toxicity studies on these compounds were also carried out. The kinetic studies on most active compounds 14 and 25 determined their modes of inhibition and dissociation constants Ki. Compound 14 was found to be a non-competitive inhibitor with Ki = 25.0 ± 0.06, while compound 25 was identified as a competitive inhibitor with Ki = 66.0 ± 0.07 μM.