530441-99-7Relevant articles and documents
Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions
Shue, Ho-Jane,Chen, Xiao,Schwerdt, John H.,Paliwal, Sunil,Blythin, David J.,Lin, Ling,Gu, Danlin,Wang, Cheng,Reichard, Gregory A.,Wang, Hongwu,Piwinski, John J.,Duffy, Ruth A.,Lachowicz, Jean E.,Coffin, Vicki L.,Nomeir, Amin A.,Morgan, Cynthia A.,Varty, Geoffrey B.,Shih, Neng-Yang
, p. 1065 - 1069 (2007/10/03)
A series of novel five-membered urea derivatives as potent NK1 receptor antagonists is described. The effects of substitution of a 4-fluoro group at the phenyl ring and the introduction of an α-methyl group at the benzylic position to improve p
Two complementary, diversity-driven asymmetric syntheses of a 2,2-disubstituted piperidine NK1 antagonist
Xiao, Dong,Wang, Cheng,Palani, Anandan,Reichard, Gregory,Aslanian, Robert,Shih, Neng-Yang,Buevich, Alexei
, p. 2596 - 2598 (2007/10/03)
Two diversity-driven asymmetric syntheses of a potent NK1 receptor antagonist 1 were achieved. These syntheses provided two complementary approaches that were well positioned for further modifications of several different sites of medicinal che