368-63-8

Basic information

• Product Name: 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL
• Synonyms: 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL;1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL;3,5-BIS(TRIFLUOROMETHYL)-A-METHYLBENZYL ALCOHOL;ALFA-METHYL-3,5-DITRIFLUOROMETHYLBENZYL ALCOHOL;alpha-Methyl-3,5-bis(trifluoromethyl)benzyl alcohol;3,5-Bis(trifluoromethyl)phenylethanol;alpha-Methyl-3,5-Bis(trifluoromethyl)Benzylalcohol99+%;à-Methyl-3,5-bis-(trifluoromethyl)-benzyl alcohol
• CAS NO: 368-63-8
• Molecular Formula: C₁₀H₈F₆O
• Molecular Weight: 258.16
• Product Categories: PHARMACEUTICAL INTERMEDIATES;Aromatic alcohols and diols
• Mol File: 368-63-8.mol
• Article Data: 153

Chemical Properties

• Melting Point: 70-74℃
• Boiling Point: 175.8 °C at 760 mmHg
• Flash Point: 60.1 °C
• Appearance: /
• Density: 1.376 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.99±0.20(Predicted)
• CAS DataBase Reference: 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL(368-63-8)
• EPA Substance Registry System: 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL(368-63-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 368-63-8(Hazardous Substances Data)

Usage

General Description

1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL is a chemical compound that belongs to the class of alcohols. It is a colorless liquid with a molecular formula C10H7F6O and a molecular weight of 274.15 g/mol. 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL is commonly used as a reagent in organic synthesis and as a building block for the production of various pharmaceuticals and agrochemicals. It is known for its strong electron-withdrawing trifluoromethyl groups, which make it a versatile building block for organic synthesis. Additionally,

Upstream product

• 112981-69-8 3,5-bis(trifluoromethyl)phenylmagnesium bromide 
• 75-07-0 acetaldehyde 
• 30071-93-3 3,5-bis(trifluoromethyl)phenyl methyl ketone 
• 849674-12-0 (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl-2,2,2-trichloroethanimidoate 
• 1021816-97-6 C₁₄H₁₇FO₂ 
• 1039339-30-4 (1-(3,5-bis-trifluoromethylphenyl)ethoxy)diphenylsilane 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 
• 349-59-7 3,5-bis(trifluoromethyl)styrene 
• 925-90-6 ethylmagnesium bromide 
• 68120-60-5 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol 
• 108-05-4 vinyl acetate 
• 69638-96-6 isopropenyl valerate 
• 534613-13-3 (R)-O-acetyl-1-(3,5-bis(trifluoromethyl)phenyl)ethanol 
• 141550-15-4 (R,R)-1,2-dicyclohexylethanediol (S)-(1-chloroethyl)boronate 

Downstream Products

• 349-59-7 3,5-bis(trifluoromethyl)styrene 
• 472968-70-0 (2R,3R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-4-((R)-1-phenyl-ethyl)-morpholine 
• 327623-36-9 (2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one 
• 287930-75-0 (2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one 
• 30071-93-3 3,5-bis(trifluoromethyl)phenyl methyl ketone 
• 225920-05-8 (S)-3,5-bis(trifluoromethyl)-1-phenylethanol 
• 368-63-8 (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol 
• 530441-95-3 (R)-1-(1-(bromomethoxy)ethyl)-3,5-bis(trifluoromethyl)benzene 
• 534613-13-3 (R)-O-acetyl-1-(3,5-bis(trifluoromethyl)phenyl)ethanol 
• 530441-99-7 2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethanone 
• 190269-66-0 1-[3,5-bis(trifluoromethyl)phenyl]ethyl 2,2,2-trichloroethaneimidate 
• 942599-73-7 [1-(3,5-bis-trifluoromethyl-phenyl)-ethoxy]-acetic acid tert-butyl ester 

Relevant articles and documents

Dynamic Kinetic Resolution of Alcohols by Enantioselective Silylation Enabled by Two Orthogonal Transition-Metal Catalysts

A nonenzymatic dynamic kinetic resolution of acyclic and cyclic benzylic alcohols is reported. The approach merges rapid transition-metal-catalyzed alcohol racemization and enantioselective Cu-H-catalyzed dehydrogenative Si-O coupling of alcohols and hydrosilanes. The catalytic processes are orthogonal, and the racemization catalyst does not promote any background reactions such as the racemization of the silyl ether and its unselective formation. Often-used ruthenium half-sandwich complexes are not suitable but a bifunctional ruthenium pincer complex perfectly fulfills this purpose. By this, enantioselective silylation of racemic alcohol mixtures is achieved in high yields and with good levels of enantioselection.

Copper-catalyzed asymmetric reductions of aryl/heteroaryl ketones under mild aqueous micellar conditions

Enantioselective syntheses of nonracemic secondary alcohols have been achieved in an aqueous micellar medium via copper-catalyzed (Cu(OAc)2·H2O/(R)-3,4,5-MeO-MeO-BIPHEP) reduction of aryl/heteroaryl ketones. This methodology serves as a green protocol to access enantio-enriched alcohols under mild conditions (0-22 °C) using a base metal catalyst, together with an inexpensive, innocuous, and convenient stoichiometric hydride source (PMHS). The secondary alcohol products are formed in good to excellent yields with ee values greater than 90%.

Tridentate nitrogen phosphine ligand containing arylamine NH as well as preparation method and application thereof

The invention discloses a tridentate nitrogen phosphine ligand containing arylamine NH as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis. The tridentate nitrogen phosphine ligand disclosed by the invention is the first case of tridentate nitrogen phosphine ligand containing not only a quinoline amine structure but also chiral ferrocene at present, a noble metal complex of the type of ligand shows good selectivity and extremely high catalytic activity in an asymmetric hydrogenation reaction, meanwhile, a cheap metal complex of the ligand can also show good selectivity and catalytic activity in the asymmetric hydrogenation reaction, and is very easy to modify in the aspects of electronic effect and space structure, so that the ligand has huge potential application value. A catalyst formed by the ligand and a transition metal complex can be used for catalyzing various reactions, can be used for synthesizing various drugs, and has important industrial application value.