53078-71-0

Basic information

• Product Name: 4-methoxy-3-methylbenzonitrile
• Synonyms: 4-methoxy-3-methylbenzonitrile;4-Cyano-2-methylanisole;4-Methoxy-3-methylbenzonitrile≥ 98% (HPLC)
• CAS NO: 53078-71-0
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.18
• Mol File: 53078-71-0.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-methoxy-3-methylbenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-3-methylbenzonitrile(53078-71-0)
• EPA Substance Registry System: 4-methoxy-3-methylbenzonitrile(53078-71-0)

Safety Data

• Hazardous Substances Data: 53078-71-0(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white solid powder

Upstream product

• 90609-89-5 β-4-methoxy-3-methyl-benzaldehyde-oxime 
• 108-24-7 acetic anhydride 
• 90609-89-5 4-methoxy-3-methyl-benzaldehyde seqtrans-oxime 
• 90609-89-5 3-methyl-4-(methyloxy)benzaldehyde oxime 
• 530-62-1 1,1'-carbonyldiimidazole 
• 557-21-1 zinc(II) cyanide 
• 175883-62-2 4-methoxy-3-methylphenylboronic acid 
• 578-58-5 2-methylmethoxybenzene 
• 4885-02-3 Dichloromethyl methyl ether 
• 75-05-8 acetonitrile 
• 32723-67-4 3-methyl-4-anisaldehyde 
• 14804-31-0 2-methyl-4-bromoanisole 
• 31418-19-6 2-methyl-3-thiocyanato-1H-indole 
• 2987-46-4 4-thiocyanatoaniline 

Downstream Products

• 6880-04-2 4-methoxy-3-methylbenzoic acid 
• 15777-70-5 4-hydroxy-3-methylbenzonitrile 
• 101207-62-9 3-bromomethyl-4-methoxybenzonitrile 
• 1260433-04-2 (3-bromophenyl)(4-methoxy-3-methylphenyl)methanimine 
• 1260433-05-3 2-(3-bromophenyl)-2-(4-methoxy-3-methylphenyl)-4-methyl-1H-imidazole-5(2H)-thione 
• 1260432-26-5 2-(3-bromophenyl)-2-(4-methoxy-3-methylphenyl)-5-methyl-2H-imidazol-4-amine 
• 1260432-27-6 2-(4-methoxy-3-methylphenyl)-5-methyl-2-(3-(pyrimidin-5-yl)phenyl)-2H-imidazol-4-amine 
• 1260432-28-7 2-(3-(5-fluoropyridin-3-yl)phenyl)-2-(4-methoxy-3-methylphenyl)-5-methyl-2H-imidazol-4-amine 

Relevant articles and documents

Oxidative cyanide-free cyanation on arylboronic acid derivatives using aryl/heteroaryl thiocyanate using novel IL-PdCl4 catalyst under mild condition

An efficient and simple method is reported for the cyanation on arylboronic acid using various simple/indole thiocyanates using a new IL-PdCl4 catalyst. The cascade process involves a coupling reaction without any additive to give a wide range of cyanide derivatives. Cyanation on various arylboronic acids underwent smoothly affording the corresponding arylnitriles in good to high yields.

Facile one-pot transformation of arenes into aromatic nitriles under metal-cyanide-free conditions

Electron-rich arenes bearing methyl or methoxy groups on the aromatic ring were treated with dichloromethyl methyl ether and ZnBr2, and then with molecular iodine and aq. ammonia to give the corresponding aromatic nitriles in good yields. Using this method, febuxostat was efficiently prepared from 4-bromophenol in four steps. The method can be used for the preparation of aromatic nitriles from arenes in one pot under metal-cyanide-free conditions. Various electron-rich arenes could be effectively converted into the corresponding aromatic nitriles in good yields, by treatment with ZnBr2 and dichloromethyl methyl ether, followed by reaction with molecular iodine and aq. ammonia.

Iron(II)-catalyzed direct cyanation of arenes with aryl(cyano)iodonium triflates

A direct oxidative cyanation of arenes under FeII catalysis with 3,5-di(trifluoromethyl)phenyl(cyano)iodonium triflate (DFCT) as the cyanating agent has been developed. The reaction is applicable to wide range of aromatic substrates, including polycyclic structures and heteroaromatic compounds. Copyright