53378-80-6

Basic information

• Product Name: Phosphonic acid, (chlorophenylmethyl)-, diethyl ester
• CAS NO: 53378-80-6
• Molecular Formula: C11H16ClO3P
• Molecular Weight: 262.673
• Mol File: 53378-80-6.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, (chlorophenylmethyl)-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, (chlorophenylmethyl)-, diethyl ester(53378-80-6)
• EPA Substance Registry System: Phosphonic acid, (chlorophenylmethyl)-, diethyl ester(53378-80-6)

Safety Data

• Hazardous Substances Data: 53378-80-6(Hazardous Substances Data)

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 415967-44-1 α-(diethoxyphosphoryl)phenylchloroacetaldehyde 
• 100-52-7 benzaldehyde 
• 100-39-0 benzyl bromide 
• 1080-32-6 O,O-diethyl benzylphosphonate 
• 209626-98-2 (Chloro-phenyl-trimethylsilanyl-methyl)-phosphonic acid diethyl ester 
• 1663-55-4 diethyl [hydroxy(phenyl)methyl]phosphonate 

Downstream Products

• 92074-50-5 ethyl α-chlorobenzylphosphonochloridate 
• 62346-69-4 diethyl α,α-dichlorobenzylphosphonate 
• 33973-24-9 diethyl (1,2-diphenyl)ethylphosphonate 
• 1181811-87-9 diethyl α,α-chlorofluorobenzylphosphonate 
• 131535-24-5 o-bis<α-(diethoxyphosphinyl)benzyloxy>benzene 
• 1127-41-9 (α-hydroxybenzyl)phosphonic acid 

Relevant articles and documents

Reactions of α-phosphoryl-α-haloacetaldehydes with difunctional nucleophiles

Reactions of phosphorylated α-haloacetaldehydes with difunctional nitrogen-, oxygen-, and sulfur-containing nucleophiles were performed with a view to synthesize C-phosphorylated heterocyclic compounds.

Mild synthesis of organophosphorus compounds: Reaction of phosphorus-containing carbenoids with organoboranes

Organoboranes react with phosphorus-containing carbenoids to produce a variety of functionalized organophosphorus compounds under mild conditions. In some cases, selective migration of one group atached to boron can be observed. Phosphonite-borane complexes are introduced as novel synthons for the synthesis of phosphinic esters.

Synthesis, reactivity and stereochemistry of new phosphorus heterocycles with 5- or 6-membered rings

Syntheses of novel phosphorus heterocycles containing α-amino or α-hydroxyphosphonic or phosphinic acids motifs are developed. 2,3-dihydro-1,3-oxaphospholes (1) and 1,4,2-oxazaphosphinanes (2) exhibit a reactive part, respectively the enolether moiety and the P-H bond, which allows various structural modifications: (i) for 1a, by introduction of amino substituents, (ii) for 2a, by hydroxy- or aminoalkylation, by Michael addition or by P-arylation. These reactions present generally a good or even an excellent kinetic diastereoselectivity which can often be predicted by molecular models of the transition states.