53391-50-7

Basic information

• Product Name: 2,2,2-TRICHLORO-1-(4-NITRO-1H-PYRROL-2-YL)-ETHANONE
• Synonyms: 2,2,2-TRICHLORO-1-(4-NITRO-1H-PYRROL-2-YL)-ETHANONE;4-NITRO-2-(TRICHLOROACETYL)-PYRROLE;2,2,2-Trichloro-1-(4-nitro-1H-pyrrol-2-yl)-ethanon;4-Nitro-2-(trichloroacetyl)-1-H-pyrrole;2,2,2-Trichloro-1-(4-nitro-1H-pyrrol-2-yl)-1-ethanone;1-(4-Nitro-1H-pyrrol-2-yl)-2,2,2-trichloroethan-1-one, 4-Nitro-2-(2,2,2-trichloroethanoyl)-1H-pyrrole
• CAS NO: 53391-50-7
• Molecular Formula: C₆H₃Cl₃N₂O₃
• Molecular Weight: 257.46
• Mol File: 53391-50-7.mol
• Article Data: 15

Chemical Properties

• Melting Point: 178-179°
• Boiling Point: 333.3°Cat760mmHg
• Flash Point: 155.4°C
• Appearance: /
• Density: 1.771g/cm³
• Vapor Pressure: 0.000138mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: -15°C
• CAS DataBase Reference: 2,2,2-TRICHLORO-1-(4-NITRO-1H-PYRROL-2-YL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRICHLORO-1-(4-NITRO-1H-PYRROL-2-YL)-ETHANONE(53391-50-7)
• EPA Substance Registry System: 2,2,2-TRICHLORO-1-(4-NITRO-1H-PYRROL-2-YL)-ETHANONE(53391-50-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 53391-50-7(Hazardous Substances Data)

Usage

General Description

2,2,2-Trichloro-1-(4-nitro-1H-pyrrol-2-yl)-ethanone is a chemical compound that consists of a trichloroethanone group and a 4-nitro-1H-pyrrol-2-yl group. It is an organochlorine compound with the molecular formula C4H2Cl3NO3. This chemical is often used in pharmaceutical and agricultural industries as a precursor for the synthesis of various organic compounds. It is a pale yellow crystalline solid with a strong odor and is considered to be toxic and potentially harmful to the environment.

InChI:InChI=1/C6H3Cl3N2O3/c7-6(8,9)5(12)4-1-3(2-10-4)11(13)14/h1-2,10H

Upstream product

• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 

Downstream Products

• 5930-92-7 Ethyl 4-nitropyrrole-2-carboxylate 
• 13138-74-4 methyl 4-nitropyrrole-2-carboxylate 
• 5930-93-8 4-nitropyrrole-2-carboxylic acid 
• 478812-28-1 4-[(t-butoxycarbonyl)amino]-1-(phthalimidopropyl)pyrrole-2-carboxylic acid 
• 67318-12-1 4-amino-2-ethoxycarbonyl-pyrrole 
• 85406-53-7 4-[(tert-butoxycarbonyl)amino]pyrrole-2-carboxylic acid 
• 1263419-21-1 6-amino-4-((1S,2R)-2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide 
• 1263419-22-2 4-((1R,2S)-2-methylcyclohexylamino)-6-nitropyrrolo[1,2-b]pyridazine-3-carbonitrile 
• 1263419-23-3 4-((1R,2S)-2-methylcyclohexylamino)-6-nitropyrrolo[1,2-b]pyridazine-3-carboxamide 
• 1263419-24-4 6-amino-4-((1R,2S)-2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide 
• 1263419-65-3 6-nitro-4-(phenylamino)pyrrolo[1,2-b]pyridazine-3-carbonitrile 
• 1263419-66-4 6-nitro-4-(phenylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide 
• 1263419-67-5 6-amino-4-(phenylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide 
• 1263419-74-4 4-(2-methylcyclohexylamino)-6-nitropyrrolo[1,2-b]pyridazine-3-carbonitrile 

Relevant articles and documents

U-pin polyamide motif for recognition of the DNA minor groove

DNA-binding hairpin pyrrole-imidazole polyamides with γ-aminobutyric acid as a turn-forming residue tolerate A · T or T · A base pairs under the turn. U-pins - polyamides with a different turn - have been synthesized and their DNA binding properties were studied. The two turn-forming residues are connected via the ring nitrogens using variable length aliphatic linkers ((CH2)n, n = 3-6). Through optimization of the linker length and the substituents at the 2-position of the pyrrole residue on the U-turn, polyamides with G · C/C · G tolerant turns could be found, which bind to DNA in a predictable manner.

Synthesis of novel 4-nitropyrrole-based semicarbazide and thiosemicarbazide hybrids with antimicrobial and anti-tubercular activity

We report the synthesis and screening of forty novel 4-nitropyrrole- semicarbazide conjugates inspired from the reported bio-potential of bromopyrrole alkaloids and semicarbazide derivatives for antimicrobial activity. Herein, hybrids 5k-5o, 5r, 5s and 5t

Synthesis and evaluation of novel 4-nitropyrrole-based 1,3,4-oxadiazole derivatives as antimicrobial and anti-tubercular agents

We report synthesis and antimicrobial evaluation of 42 novel 4-nitropyrrole-based 1,3,4-oxadiazoles. The synthesized molecules were evaluated for anti-bacterial, anti-fungal and anti-tubercular activities. Promisingly, most of the compounds showed equal o