67318-12-1

Basic information

• Product Name: 4-AMINO-1H-PYRROLE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 4-AMINO-1H-PYRROLE-2-CARBOXYLIC ACID ETHYL ESTER;ethyl 4-amino-1H-pyrrole-2-carboxylate;Ethyl 4-aminopyrrole-2-carboxylate;1H-Pyrrole-2-carboxylicacid, 4-aMino-, ethyl ester
• CAS NO: 67318-12-1
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.1665
• Mol File: 67318-12-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 349℃
• Flash Point: 165℃
• Appearance: /
• Density: 1.238
• Vapor Pressure: 4.91E-05mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 15.93±0.50(Predicted)
• CAS DataBase Reference: 4-AMINO-1H-PYRROLE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-1H-PYRROLE-2-CARBOXYLIC ACID ETHYL ESTER(67318-12-1)
• EPA Substance Registry System: 4-AMINO-1H-PYRROLE-2-CARBOXYLIC ACID ETHYL ESTER(67318-12-1)

Safety Data

• Hazardous Substances Data: 67318-12-1(Hazardous Substances Data)

Usage

General Description

4-Amino-1H-pyrrole-2-carboxylic acid ethyl ester is a chemical compound with the molecular formula C8H10N2O2. It is an ethyl ester of 4-amino-1H-pyrrole-2-carboxylic acid, which is an important building block in the synthesis of various pharmaceuticals and agrochemicals. 4-AMINO-1H-PYRROLE-2-CARBOXYLIC ACID ETHYL ESTER is commonly used as an intermediate in the production of various organic compounds and has potential applications in the pharmaceutical industry due to its unique chemical properties. It can be used in the synthesis of pyrrole-based compounds, which have been studied for their potential biological activities and medicinal properties. Additionally, it has been found to exhibit antimicrobial and antifungal properties, further demonstrating its potential as a valuable chemical in various industrial applications.

InChI:InChI=1/C7H10N2O2/c1-2-11-7(10)6-3-5(8)4-9-6/h3-4,9H,2,8H2,1H3

Upstream product

• 5930-92-7 Ethyl 4-nitropyrrole-2-carboxylate 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 53391-50-7 2,2,2-trichloro-1-(4-nitro-1H-pyrrol-2-yl)ethan-1-one 

Downstream Products

• 85406-53-7 4-[(tert-butoxycarbonyl)amino]pyrrole-2-carboxylic acid 
• 161952-14-3 N-(2-ethoxycarbonyl-4-pyrrolyl)-3-acetylthio-2-(4-chlorobenzyl)-propanamide 
• 1132610-84-4 5-methyl-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester 
• 1443775-81-2 C₂₉H₃₆N₄O₆ 
• 1443775-96-9 C₃₁H₄₀N₄O₆ 
• 1443775-99-2 C₃₂H₃₄N₄O₆ 

Relevant articles and documents

Modular preparation of diverse dipyrrolemethanes

A modular synthesis of polyfunctional dipyrrolemethanes is presented. Diverse side chains are introduced to 2-carboxypyrrole building blocks in two to four steps, resulting in a collection of substituted pyrroles that, when condensed in one step, give ris

2,3-SUBSTITUTED AZAINDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS

The present invention relates to 2,3-Substituted Azaindole Derivatives, compositions comprising at least one 2,3-Substituted Azaindole Derivatives, and methods of using the 2,3-Substituted Azaindole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

Recognition of the DNA minor groove by pyrrole-imidazole polyamides: Comparison of desmethyl- and N-methylpyrrole

Polyamides consisting of N-methylpyrrole (Py), N-methylimidazole (Im), and N-methyl-3-hydroxypyrrole (Hp) are synthetic ligands that recognize predetermined DNA sequences with affinities and specificities comparable to many DNA-binding proteins. As derivatives of the natural products distamycin and netropsin, Py/Im/Hp polyamides have retained the N-methyl substituent, although structural studies of polyamide:DNA complexes have not revealed an obvious function for the N-methyl. In order to assess the role of the N-methyl moiety in polyamide:DNA recognition, a new monomer, desmethylpyrrole (Ds), where the N-methyl moiety has been replaced with hydrogen, was incorporated into an eight-ring hairpin polyamide by solid-phase synthesis. MPE footprinting, affinity cleavage, and quantitative DNase I footprinting revealed that replacement of each Py residue with Ds resulted in identical binding site size and orientation and similar binding affinity for the six-base-pair (bp) target DNA sequence. Remarkably, the Ds-containing polyamide exhibited an 8-fold loss in specificity for the match site versus a mismatched DNA site, relative to the all-Py parent. Polyamides with Ds exhibit increased water solubility, which may alter the cell membrane permeability properties of the polyamide. The addition of Ds to the repertoire of available monomers may prove useful as polyamides are applied to gene regulation in vivo. However, the benefits of Ds incorporation must be balanced with a potential loss in specificity. Copyright (C) 2000 Elsevier Science Ltd.