53502-60-6

Basic information

• Product Name: 1-(2-chloroethyl)piperazine
• Synonyms: 1-(2-chloroethyl)piperazine dihydrochloride
• CAS NO: 53502-60-6
• Molecular Formula: C₆H₁₃ClN₂*2ClH
• Molecular Weight: 0
• Mol File: 53502-60-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 222.4°C at 760 mmHg
• Flash Point: 88.3°C
• Appearance: /
• Density: 1.042g/cm³
• Vapor Pressure: 0.102mmHg at 25°C
• Refractive Index: 1.466
• CAS DataBase Reference: 1-(2-chloroethyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)piperazine(53502-60-6)
• EPA Substance Registry System: 1-(2-chloroethyl)piperazine(53502-60-6)

Safety Data

• Hazardous Substances Data: 53502-60-6(Hazardous Substances Data)

Usage

General Description

1-(2-chloroethyl)piperazine is a chemical compound consisting of a piperazine ring with a 2-chloroethyl substituent. It is classified as an organochlorine compound and is used in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential use as a drug delivery agent and as a building block for the development of new bioactive compounds. As a chlorinated compound, it may pose environmental and health risks, and caution should be taken in its handling and disposal.

InChI:InChI=1/C6H13ClN2/c7-1-4-9-5-2-8-3-6-9/h8H,1-6H2

Upstream product

• 5712-71-0 1-(2-hydroxyethyl)piperazine dihydrochloride 
• 110-85-0 piperazine 
• 107-15-3 ethylenediamine 
• 107-06-2 1,2-dichloro-ethane 
• 103-76-4 1-(2-hydroxyethyl)piperazine 

Downstream Products

• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 19479-83-5 1,2-bis(piperazinyl)-ethane 
• 24028-46-4 1-<2-(2-aminoethyl)aminoethyl>piperazine 
• 314726-14-2 4,6-Diamino-2-[2-(4-acetyl-1-piperazinyl)ethylthio]-5-(2-methoxybenzyl)pyrimidine 
• 314725-98-9 4,6-Diamino-5-(2-methoxybenzyl)-2-[2-(1-piperazinyl)ethylthio]-pyrimidine 
• 314725-99-0 4,6-Diamino-5-(2-methoxybenzyl)-2-[2-(1-piperazinyl)ethylthio]-pyrimidine fumarate 
• 314726-23-3 4,6-Diamino-2-[2-(1-piperazinyl)ethylthio]-5-(4-isopropylbenzyl)-pyrimidine 
• 137554-12-2 Ethyl-(2-piperazin-1-yl-ethyl)-amine 

Relevant articles and documents

Amine ethylated piperazine and preparation method thereof

The invention provides a preparation method of an amine ethylated piperazine, and relates to the technical field of preparation of aminoethyl piperazine. The method comprises the following steps: mixing a piperazine compound, a chlorination reagent and a soluble piperazine compound solvent to carry out chlorination reaction to obtain the chloropiperazine hydrochloride. The piperazine compound comprises 2 - hydroxyethyl piperazine or N, N' - bis (2 - hydroxyethyl) piperazine. The chloropiperazine hydrochloride, the organic amine and the water are mixed, and the substitution reaction is carried out to obtain the aminated piperazine. The organic amine includes methylamine. Diethylamine, propylamine. The preparation method provided by the invention is high in product yield, high in purity, simple to operate, wide in reaction raw material source, low in production cost and suitable for industrial production.

MECHANISM OF THE REACTION OF 1,2-DICHLOROETHANE WITH ETHYLENEDIAMINE

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