24028-46-4

Basic information

• Product Name: N-[2-(1-piperazinyl)ethyl]ethylenediamine
• Synonyms: N-[2-(1-piperazinyl)ethyl]ethylenediamine;1,2-Ethanediamine, N-2-(1-piperazinyl)ethyl-;1,2-Ethanediamine,N-[2-(1-piperazinyl)ethyl]-(9CI);N-[2-(1-piperazinyl)ethyl]-1,2-Ethanediamine;n-[2-(1-piperazinyl)ethyl]-2-ethanediamine;N-(2-PIPERAZIN-1-YLETHYL)ETHANE-1,2-DIAMINE;piperazinylethylethylenediamine;N-(2-Piperazinoethyl)-1,2-ethanediamine
• CAS NO: 24028-46-4
• Molecular Formula: C₈H₂₀N₄
• Molecular Weight: 172.2712
• EINECS: 245-992-8
• Product Categories: PIPERIDINE
• Mol File: 24028-46-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 292.5°C at 760 mmHg
• Flash Point: 130.7°C
• Appearance: /
• Density: 0.975g/cm³
• Vapor Pressure: 0.00183mmHg at 25°C
• Refractive Index: 1.49
• PKA: 10.04±0.19(Predicted)
• CAS DataBase Reference: N-[2-(1-piperazinyl)ethyl]ethylenediamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(1-piperazinyl)ethyl]ethylenediamine(24028-46-4)
• EPA Substance Registry System: N-[2-(1-piperazinyl)ethyl]ethylenediamine(24028-46-4)

Safety Data

• RIDADR: 2735
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 24028-46-4(Hazardous Substances Data)

Usage

Uses

N1-[2-(1-Piperazinyl)ethyl]-1,2-ethanediamine is an impurity of Diethylenetriamine (D444255); a compound that is used in biological studies for polyamines inhibition to carbonic anhydrases by anchoring to the zinc-coordinated water molecule.

InChI:InChI=1/C8H20N4/c9-1-2-10-3-6-12-7-4-11-5-8-12/h10-11H,1-9H2

Upstream product

• 64-17-5 ethanol 
• 107-15-3 ethylenediamine 
• 106-93-4 ethylene dibromide 
• 6780-13-8 1,2-ethanediamine monohydrate 
• 151-56-4 ethyleneimine 
• 140-31-8 aminoethylpiperazine 
• 4025-37-0 1-(2-amino-ethyl)-aziridine 
• 110-85-0 piperazine 
• 60068-45-3 N-[2-(2-Amino-ethylamino)-ethyl]-N'-(2-chloro-ethyl)-ethane-1,2-diamine 
• 53502-60-6 1-(2-chloroethyl)-piperazine dihydrochloride 
• 107-06-2 1,2-dichloro-ethane 
• 1051939-66-2 diethylenetriaminediacetonitrile 
• 112-24-3 triethylentetramine 
• 112-57-2 N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine 

Downstream Products

• 31295-54-2 1-(2-aminoethyl)-4-<(2-aminoethyl)aminoethyl> piperazine 
• 31295-49-5 N-(2-aminoethyl)-N'-[2-(1-piperazinyl)ethyl]ethylenediamine 

Relevant articles and documents

METHODS OF MAKING CYCLIC, N-AMINO FUNCTIONAL TRIAMINES

The present invention provides strategies for making cyclic triamines. Reactant media including certain precursors and/or certain types of catalysts can be converted into cyclic triamines with improved conversion and selectivity. The strategies can be incorporated into reactions that involve transamination schemes and/or reductive amination schemes. In the case of transamination, for instance, using transamination to cause ring closure of higher amines in the presence of a suitable catalyst leads to desired cyclic triamines with notable conversion and yield. In the case of reductive amination, reacting suitable polyfunctional precursors in the presence of a suitable catalyst also yields cyclic triamines via ring closure with notable selectivity and conversion. Both transamination and reductive amination methodologies can be practiced under much milder temperatures than are used when solely acid catalysts are used. Preferred embodiments can produce reaction mixtures that are generally free of salt by-products.

REGIOCHEMISTRY AND KINETICS OF CYCLIZATION OF N-(2-CHLOROETHYL)POLYETHYLENEPOLYAMINES

The directions of competitive intramolecular cyclization of a series of N-(2-chloroethyl)polyethylenepolyamines yielding 3- and 6-member nitrogen-containing heterocycles were investigated.The kinetic characteristics of these reactions were studied.A qualitative scheme for synthesis of polyethylenepolyamines that explains the practically observed characteristics was proposed based on the results obtained and the published data.

KINETICS AND MECHANISM OF THE REACTION OF 1,2-DICHLOROETHANE WITH PIPERAZINE

-