53623-37-3

Basic information

• Product Name: 3-(4-ETHOXYBENZOYL)PROPIONIC ACID
• Synonyms: 3-(4-ETHOXYBENZOYL)PROPIONIC ACID;4-ETHOXY-GAMMA-OXO-BENZENEBUTANOIC ACID;4-(4-ETHOXYPHENYL)-4-OXOBUTANOIC ACID;4-(4-ETHOXYPHENYL)-4-OXOBUTYRIC ACID
• CAS NO: 53623-37-3
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.24
• Mol File: 53623-37-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 136 °C
• Boiling Point: 426.7°Cat760mmHg
• Flash Point: 166.6°C
• Appearance: /
• Density: 1.175g/cm³
• Vapor Pressure: 4.86E-08mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.59±0.17(Predicted)
• CAS DataBase Reference: 3-(4-ETHOXYBENZOYL)PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-ETHOXYBENZOYL)PROPIONIC ACID(53623-37-3)
• EPA Substance Registry System: 3-(4-ETHOXYBENZOYL)PROPIONIC ACID(53623-37-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 53623-37-3(Hazardous Substances Data)

Usage

General Description

3-(4-Ethoxybenzoyl)Propionic Acid is an organic compound composed mainly of carbon, hydrogen and oxygen. As the name suggests, it contains an ethoxybenzoyl group attached to a propionic acid group, which could contribute to its potential properties and uses. 3-(4-ETHOXYBENZOYL)PROPIONIC ACID can fall under categories of benzoyl compounds or carboxylic acids depending on its functional groups. Its specific properties, such as melting point, boiling point, acidity or alkalinity, solubility, etc., would be determined by its specific molecular structure. Further information including synthesis methods and detailed properties would require a more detailed analysis or research. Currently, there is not a substantial amount of publicly available data about this specific compound, so its applications in industries such as pharmaceuticals, agriculture, or manufacturing are not yet clear.

InChI:InChI=1/C12H14O4/c1-2-16-10-5-3-9(4-6-10)11(13)7-8-12(14)15/h3-6H,2,7-8H2,1H3,(H,14,15)/p-1

Upstream product

• 108-30-5 succinic acid anhydride 
• 103-73-1 Phenetole 
• 74-96-4 ethyl bromide 
• 66123-43-1 4-(4-hydroxyphenyl)-4-oxobutanoic acid ethyl ester 

Downstream Products

• 319494-44-5 4-(4-ethoxy-phenyl)-4-oxo-butyric acid methyl ester 
• 95152-07-1 6-(4-ethoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one 
• 58472-30-3 (4-ethoxyphenyl)butanoic acid 
• 74362-69-9 4-(4-ethoxy-3-nitro-phenyl)-4-oxo-butyric acid 
• 124-38-9 carbon dioxide 
• 619-86-3 4-(ethoxy)benzoic acid 
• 79-10-7 acrylic acid 
• 141-82-2 malonic acid 
• 905590-59-2 N-(5-benzyl-4-phenyl-1,3-thiazol-2-yl)-4-(4-ethoxyphenyl)-4-oxobutanamide 

Relevant articles and documents

Design, Synthesis, and Pharmacological Screening of Pyridazinone Hybrids as Anticonvulsant Agents

A series of new hybrid benzimidazole containing pyridazinones derivatives were designed and synthesized in accordance with the pharmacophoric requirements essential for the anticonvulsant activity. The synthesized compounds were evaluated for anticonvulsant activity on mice by the gold standard maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ)-induced seizure models. Among the compounds tested, SS-4F showed significant anticonvulsant activity in both the screens with ED50 values of 25.10 and 85.33 mg/kg in the MES and scPTZ screens, respectively. Compound SS-4F emerged as safer and effective anticonvulsant due to its several-fold higher protective indices. Further, the gamma-aminobutyric acid (GABA) estimation result showed a marked increase in the GABA level (1.7-fold) as compared to the control, which was further confirmed by good binding properties with the GABAA receptor.

AMIDE COMPOUND

Disclosed is a compound represented by the formula (I) or (II) below, or a salt thereof. [In the formulae, ring A represents an optionally substituted ring (which is not a pyrrolidine, piperidine or piperazine); ring B represents an optionally substituted aromatic ring; ring D represents an optionally substituted ring; R1 and R2 independently represent a hydrogen atom or a substituent; R3 represents a hydrogen atom or a C1-6 alkyl group, or alternatively it combines with the ring A to form a non-aromatic ring; ring Aa represents an optionally substituted aromatic hydrocarbon; Y represents CH or N; Ra1 represents an optionally substituted hydrocarbon group; and Ra2 and Ra3 independently represent a hydrogen atom or a substituent.] The compound has a DGAT inhibitory effect and is useful for treatment or improvement of diseases or conditions caused by high expression or high activation of DGAT.

Syntheses and antiinflammatory activity of some 6-aryl-2,3,4,5-tetrahydro-3-pyridazinones

6-Aryl-2, 3, 4, 5-tetrahydro-3-pyridazinones (2c-22c) are obtained by dehydrocyclisation of various hydrazides formed by the reaction of appropriate methyl β-aroylpropionate and hydrazine hydrate in the presence of anhydrous sodium acetate. They show promising antiinflammatory activity during their evaluation by carrageenin induced paw edema test in rats.