53899-19-7

Basic information

• Product Name: 8-methoxy-3,4-dihydroquinolin-2(1H)-one
• Synonyms: 8-methoxy-3,4-dihydroquinolin-2(1H)-one;3,4-dihydro-8-methoxy-2(1H)-quinolinone
• CAS NO: 53899-19-7
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.19984
• Mol File: 53899-19-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-methoxy-3,4-dihydroquinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-methoxy-3,4-dihydroquinolin-2(1H)-one(53899-19-7)
• EPA Substance Registry System: 8-methoxy-3,4-dihydroquinolin-2(1H)-one(53899-19-7)

Safety Data

• Hazardous Substances Data: 53899-19-7(Hazardous Substances Data)

Upstream product

• 52749-50-5 3,4-dihydro-8-hydroxy-2(1H)-quinolinone 
• 74-88-4 methyl iodide 
• 105910-09-6 ethyl 3-methoxy-2-nitrocinnamate 
• 22614-69-3 8-methoxy-1H-quinolin-2-one 
• 15450-76-7 8-Hydroxy-1H-quinolin-2-one 
• 55860-23-6 N-(methoxyphenyl)-3-chloropropionamide 
• 90-04-0 2-methoxy-phenylamine 
• 74668-74-9 2-chloro-8-methoxy-quinoline 
• 10516-71-9 3-(3-Methoxy-phenyl)-propionic acid 
• 67363-17-1 N-Hydroxy-3-(3-methoxy-phenyl)-propionamide 
• 6342-77-4 2-methoxy-benzenepropanoic acid 

Downstream Products

• 93609-53-1 5-Acetyl-8-benzyloxy-3,4-dihydro-1H-quinolin-2-one 
• 93609-58-6 8-Benzyloxy-5-{1-[(E)-hydroxyimino]-ethyl}-3,4-dihydro-1H-quinolin-2-one 
• 93609-61-1 8-Benzyloxy-5-{1-[(Z)-oxiranylmethoxyimino]-ethyl}-3,4-dihydro-1H-quinolin-2-one 
• 93609-73-5 8-Hydroxy-5-{1-[(Z)-2-hydroxy-3-(1-methyl-2-phenyl-ethylamino)-propoxyimino]-ethyl}-3,4-dihydro-1H-quinolin-2-one 
• 93609-64-4 5-(1-{(Z)-3-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxyimino}-ethyl)-8-methoxy-3,4-dihydro-1H-quinolin-2-one 
• 93609-67-7 8-Benzyloxy-5-(1-{(Z)-3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxyimino}-ethyl)-3,4-dihydro-1H-quinolin-2-one 

Relevant articles and documents

Room Temperature Benzofused Lactam Synthesis Enabled by Cobalt(III)-Catalyzed C(sp2)?H Amidation

Benzofused lactams, especially indolin-2-one and dihydroquinolin-2-one are popular structural motives in durgs and natural products. Herein, we developed a room temperature and robust synthesis of benzofused lactams through cobalt(III)-catalyzed C(sp

Revisiting Arene C(sp2)?H Amidation by Intramolecular Transfer of Iridium Nitrenoids: Evidence for a Spirocyclization Pathway

Two mechanistic pathways, that is, electrocyclization and electrophilic aromatic substitution, are operative in most intramolecular C?H amination reactions proceeding by metal nitrenoid catalysis. Reported here is an alternative mechanistic scaffold leading to benzofused δ-lactams selectively. Integrated experimental and computational analysis revealed that the reaction proceeds by a key spirocyclization step followed by a skeletal rearrangement. Based on this mechanistic insight, a new synthetic route to spirolactams has been developed.

Cardiotonic agents. 2. Synthesis and structure-activity relationships in a new class of 6-, 7-, and 8-pyridyl-2(1H)-quinolone derivatives

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