5421-40-9

Basic information

• Product Name: 4'-methoxybutyranilide
• Synonyms: 4'-methoxybutyranilide;N-(4-Methoxyphenyl)butanamide
• CAS NO: 5421-40-9
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.2423
• EINECS: 226-539-3
• Mol File: 5421-40-9.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 365.8°Cat760mmHg
• Flash Point: 175°C
• Appearance: /
• Density: 1.076g/cm³
• CAS DataBase Reference: 4'-methoxybutyranilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-methoxybutyranilide(5421-40-9)
• EPA Substance Registry System: 4'-methoxybutyranilide(5421-40-9)

Safety Data

• Hazardous Substances Data: 5421-40-9(Hazardous Substances Data)

Usage

General Description

4'-methoxybutyranilide, also known as 4-methoxy-N-butylacetanilide, is a chemical compound that is commonly used as a fragrance ingredient in cosmetics and personal care products. It belongs to the class of compounds known as acetanilides, which are organic compounds containing an acetamide group conjugated to a phenyl group. 4'-methoxybutyranilide has a slightly sweet, floral scent and is often used in perfumes, lotions, and other scented products. In addition to its use in the fragrance industry, it has also been studied for its potential antimicrobial and anti-inflammatory properties. However,

Upstream product

• 106-31-0 butanoic acid anhydride 
• 104-94-9 4-methoxy-aniline 
• 141-75-3 butyryl chloride 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 61829-43-4 N-butyl-4-methoxyaniline 
• 541-35-5 butanamide 
• 696-62-8 para-iodoanisole 
• 100-17-4 para-methoxynitrobenzene 
• 627-05-4 1-nitrobutane 
• 100-66-3 methoxybenzene 
• 107-92-6 butyric acid 
• 423115-90-6 1-(4-methoxyphenyl)butanone oxime 
• 623-42-7 butanoic acid methyl ester 
• 693-03-8 n-butyl magnesium bromide 

Downstream Products

• 122846-18-8 N-<(tert-butoxycarbonyl)methyl>-N-(4-methoxyphenyl)butanamide 
• 35274-21-6 N-(4-methoxyphenyl)butanethioamide 
• 117901-09-4 cis-4-(tert-butoxycarbonyl)-3-ethyl-1-(4-methoxyphenyl)-2-azetidinone 
• 137242-80-9 S-methyl N-(4-methoxyphenyl)-butanethioimidate 
• 137242-85-4 trans-1-(4-methoxyphenyl)-3-phenoxy-4-(n-propyl)-4-methylthio-azetidin-2-one 
• 137242-86-5 trans-1-(4-methoxyphenyl)-3-phthalimido-4-(n-propyl)-4-methylthio-azetidin-2-one 

Relevant articles and documents

Organocatalytic and enantioselective [4+2] cyclization between hydroxymaleimides and: Ortho -hydroxyphenyl para -quinone methide-selective preparation of chiral hemiketals

A cinchona alkaloid squaramide promoted enantioselective [4+2] cyclization between hydroxymaleimides and ortho-hydroxyphenyl p-QMs has been disclosed, and a wide range of chiral hemiketals containing chromane and succinimide frameworks with two adjacent quaternary stereogenic centers have been prepared for the first time with excellent results (up to 99% yield, up to 99?:?1 dr, up to >99% ee) under mild conditions. This journal is

Catalyst-Free Transamidation of Aromatic Amines with Formamide Derivatives and Tertiary Amides with Aliphatic Amines

A simple catalyst- and promoter-free protocol has been developed for the transamidation of weakly nucleophilic aromatic amines with formamide derivatives and low-reactivity tertiary amides with aliphatic amines. This strategy is advantageous because no catalyst or promoters are needed, no additives are required, separation and purification is easy, and the reaction is scalable. Significantly, this strategy was further applied to synthesize several pharmaceutical molecules on a gram scale, and excellent yields were achieved.

Catalyst- and Supporting-Electrolyte-Free Electrosynthesis of Benzothiazoles and Thiazolopyridines in Continuous Flow

A catalyst- and supporting electrolyte-free method for electrochemical dehydrogenative C?S bond formation in continuous flow has been developed. A broad range of N-arylthioamides have been converted to the corresponding benzothiazoles in good to excellent yields and with high current efficiencies. This transformation is achieved using only electricity and laboratory grade solvent, avoiding degassing or the use of inert atmosphere. This work highlights three advantages of electrochemistry in flow, which is (i) a supporting electrolyte-free reaction, (ii) an easy scale-up of the reaction without the need for a larger reactor and, (iii) the important and effective impact of having a good mixing of the reaction mixture, which can be achieved effectively with the use of flow systems. This clearly improves the reported methods for the synthesis of benzothiazoles.