54930-39-1

Basic information

• Product Name: 3-(4-methylphenyl)propan-1-amine
• Synonyms: UKRORGSYN-BB BBV-182394;3-(4-methylphenyl)propan-1-amine(SALTDATA: FREE);4-Methyl-benzenepropanaMine;[3-(4-methylphenyl)propyl]amine;3-(4-methylphenyl)propylamine;3-(4-methylphenyl)propan-1-amine;OTAVA-BB 1038710
• CAS NO: 54930-39-1
• Molecular Formula: C₁₀H₁₅N
• Molecular Weight: 149.23
• Mol File: 54930-39-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 239.219°C at 760 mmHg
• Flash Point: 103.403°C
• Appearance: /
• Density: 0.94g/cm³
• Vapor Pressure: 0.041mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: 3-(4-methylphenyl)propan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methylphenyl)propan-1-amine(54930-39-1)
• EPA Substance Registry System: 3-(4-methylphenyl)propan-1-amine(54930-39-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 54930-39-1(Hazardous Substances Data)

Usage

General Description

3-(4-methylphenyl)propan-1-amine, also known as 4-Methylamphetamine, is a chemical compound with the formula C10H15N. It is a psychoactive drug and a stimulant of the amphetamine class that is structurally related to methamphetamine. 4-Methylamphetamine is a potent and addictive psychoactive substance that produces effects such as increased energy, alertness, and euphoria. It functions by increasing the levels of certain neurotransmitters in the brain, particularly dopamine and norepinephrine, leading to its stimulating effects. 3-(4-methylphenyl)propan-1-amine is illegal in most countries and is classified as a controlled substance due to its potential for abuse and addiction. It is commonly used as a recreational drug but can also have harmful effects on the body and mind, including cardiovascular issues, anxiety, and psychological dependence.

InChI:InChI=1/C10H15N/c1-9-4-6-10(7-5-9)3-2-8-11/h4-7H,2-3,8,11H2,1H3

Upstream product

• 32327-69-8 1-cyano-2-(4'-methylphenyl)ethane 
• 5259-97-2 [1,3]oxazinan-2-one 
• 108-88-3 toluene 
• 332-42-3 (2-bromoethyl)-4-fluorobenzene 
• 25468-86-4 3-(4'-fluorophenyl)propanenitrile 
• 104-81-4 4-Methylbenzyl bromide 
• 28446-70-0 (E/Z)-3-(4-methylphenyl)propenenitrile 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 121654-82-8 2-Cyclohexanecarbonyl-11-methyl-2,3,6,7,8,12b-hexahydro-1H-benzo[3,4]azepino[1,2-a]pyrazin-4-one 
• 1403029-82-2 3-(4-fluorophenyl)propyl carbamic acid methyl ester 
• 1017789-58-0 8-fluoro-2,3,4,5-tetrahydro-benzo[c]azepin-1-one 
• 101488-65-7 3-(4-fluorophenyl)propan-1-amine 

Relevant articles and documents

8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study

β2-Agonists that bind to plasmalemmal β2-adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β2-agonistic activities with a cellular cAMP assay. Compounds B05 and C08 were identified as potent (EC50 2-agonists among the compounds tested. They behaved as partial β2-agonists in non-overexpressed HEK293 cells, and possessed rapid smooth muscle relaxant actions and long duration of action in isolated guinea pig tracheal strip preparations. In summary, B05 and C08 are β2-agonists with potential applicability in chronic respiratory diseases.

Transition-metal-free Intramolecular C-H amination of sulfamate esters and: N -alkylsulfamides

The transition-metal-free intramolecular C-H amination of sulfamate esters using iodine oxidants, tert-butyl hypoiodite (t-BuOI) and N-iodosuccinimide (NIS) is reported. A method using NIS was also successfully applied to the oxidative cyclization of N-alkylsulfamides.

Buttressing Salicylaldehydes: A Multipurpose Directing Group for C(sp3)?H Bond Activation

A palladium-catalyzed reaction of primary amines with iodoarenes produces γ-arylated primary amines. A bulky salicylaldehyde, which is marked as easily available, installable, removable, and recoverable, plays a key role in directing palladium to site-selectively activate the C?H bond located γ to the amino group.